不同剂量舒芬太尼对腹部手术患者静脉镇痛的效果研究  

Research of Optimal Dose of Sufentanil for Abdominal Intravenous Analgesia

作　　者：陆叶[1] 苏露露[1] 苗素琴[1] 吕德珍[1] 高红[1] 韩蓓[2] 

机构地区：[1]南京军区南京总医院麻醉科,江苏南京210009 [2]南京医科大学,江苏南京210029

出　　处：《河北医学》2015年第4期529-532,共4页Hebei Medicine

基　　金：国家自然科学基金青年项目;(编号:30901627)

摘　　要：目的:探讨不同剂量舒芬太尼对腹部手术患者术后静脉镇痛的效果。方法:选择我院2012年7月至2014年7月择期行腹部外科手术的患者90例,按照随机数字表法将所选病例分为三组,每组30例。其中A组患者给予舒芬太尼负荷剂量0.5μg/m L,B组给予0.75μg/m L,C组给予1.00μg/m L。观察并比较三组患者术后疼痛评分和不良反应的发生率。结果:术后12h,三组患者的疼痛评分无显著性差异(P>0.05)。术后24h,C组患者疼痛明显缓解,且疼痛评分低于A组和B组,差异具有统计学意义(P<0.05);A组与B组之间比较无显著差异(P>0.05)。三组患者不良反应发生率无显著差异(P>0.05)。结论:选用舒芬太尼负荷剂量1.00μg/m L,维持2μg/m L是腹部手术患者术后静脉镇痛的理想剂量。Objective：To investigate the optimal dose of sufentanil for pediatric abdominal surgery in-travenous analgesia .Method： 90 patients who had taken the abdominal surgery in our hospital from Jul . 2012 to Jul.2014 were selected and randomly divided into three groups , with 30 in each group.The patients in group A were given sufentanil with 0.5 μg/mL, the patients in group B were given sufentanil with 0.75μg/mL and the patients in group C were given sufentanil with 1.00 μg/mL.Then the pain scores and inci-dence of adverse reactions of patients in the three groups after the anestheasia were observed and compared . Result：There was no statistically significant difference about the pain scores and the adverse reactions of pa -tients in the three groups after the surgery for 12 hours （ P＆gt;0.05） .The pain score of patients in group C was higher than those of the patients in group A and group B with statistically significant differences after the sur -gery for 24 hours （P＆lt;0.05）.There was no statistically significant difference about the pain score between group A and group B after the surgery for 24 hours （P＆gt;0.05）.There was no statistically significant difference about the incidence of adverse reactions of patients in the three groups （P＆gt;0.05）.Conclusion：The loading dose of sufentanil with 1.00μg/mL and maintenance with 2.00μg/mL would be the optimal dose in abdomi-nal surgery as intravenous analgesia .

关 键 词：舒芬太尼 腹部手术 镇痛效果 

分 类 号：R614[医药卫生—麻醉学]