通心络胶囊治疗72例糖尿病心肌病的临床观察  

Clinical Observation on Tongxinluo Capsule in the Treatment of 72 Cases Diabetic Cardiomyopathy

作　　者：王丽[1] 袁全才 李亮[1] 

机构地区：[1]四川省自贡市第二人民医院心内科,四川自贡643000

出　　处：《河北医学》2015年第4期665-668,共4页Hebei Medicine

基　　金：2011年四川省卫生厅科研课题项目;(编号:110125)

摘　　要：目的:探讨通心络胶囊佐治糖尿病心肌病的药物疗效。方法:将纳入对照研究的72例糖尿病心肌病患者按随机数字表法分成2组:对照组36例给予降血糖、降血压、调脂等常规治疗;观察组36例再口服通心络胶囊治疗。比较两组血糖水平、血液流变学、心脏结构及功能参数值的变化情况。结果:观察组治疗后的FBG、PBG、Hb A1c血糖指标水平优于对照组(P<0.05);观察组治疗后的ηb、ηp、Fg血液流变学指标水平的改善程度比对照组显著(P<0.05);观察组治疗后的LAd、LVEDd、IVSd、LVPWd心脏结构指标水平和EF、FS、PE、PA、E/A心脏功能指标水平明显优于对照组(P<0.05)。结论:通心络胶囊佐治糖尿病心肌病能够改善血液流变学和心肌重构,促进心脏功能恢复和提高。Objective： To investigate the efficacy of Tongxinluo capsule in the treatment of diabetic cardiomyopathy. Method： 72 cases of diabetic cardiomyopathy patients were randomly divided into two groups,control group（ n = 36） and observation group（ n = 36）,the control group was given lower blood sugar,blood pressure,lipid and other conventional treatment,and the observation group was given Tongxinluo capsule.The parameter of blood sugar levels,blood rheology,cardiac structure and function in 2 groups was compared. Result： After 4 weeks of treatment,the level of FBG,PBG,Hb A1 c in the observation group was significantly better than the control group（ P 0.05）; the degree of improvement hemorheology about ηb,ηp and Fg in the observation group was significantly higher than the control group（ P 0.05）; the cardiac structure parameters about LAd,LVEDd,IVSd,LVPWd and the cardiac function parameters about EF,FS,PE,PA,E / A in the observation group was significantly better than the control group（ P 0. 05）. Conclusion：Tongxinluo capsule in the treatment of diabetic cardiomyopathy can improve blood rheology and myocardial remodeling,and promote recovery and improve heart function.

关 键 词：糖尿病心肌病 通心络胶囊 血液流变学 心脏功能 

分 类 号：R587.2[医药卫生—内分泌]