低共熔溶剂中新型螺环吲哚衍生物的绿色合成  

Green Synthesis of Novel Spirooxindole Derivatives in Deep Eutectic Solvent

作　　者：严楠[1,2] 熊云奎[2] 夏剑辉[2] 芮培欣[2] 雷志伟 廖维林 熊斌[1,2] 

机构地区：[1]国家单糖化学合成工程技术研究中心,南昌330027 [2]江西师范大学化工研发中心,南昌330027

出　　处：《有机化学》2015年第2期384-389,共6页Chinese Journal of Organic Chemistry

基　　金：国家科技支撑计划(No.2009BAI75B02);江西省研究生创新基金(No.YC2014-B030);江西师范大学优秀博士论文培育计划资助项目~~

摘　　要：在低共熔溶剂氯化胆碱/草酸催化作用下,由醛、吲哚和6,10-二氧杂螺[4.5]十烷-7,9-二酮三组分多米诺Knoevenagel-Michael反应合成了一系列新型螺环吲哚衍生物,产率为70%-97%.该方法条件温和,操作简单,反应时间短,对环境友好等优点,且催化剂廉价易得.A series of novel spirooxindole derivatives were synthesized by three-component domino Knoevenagel-Michael reaction between aldehydes, indole and 6,10-dioxaspiro[4.5]decane-7,9-dione using the deep eutectic solvent（DES） choline chloride-oxalic acid as a catalyst in 70%-97% yields. This method has some distinct advantages such as easy work-up, mild reaction conditions, short reaction time, environmental friendliness and accessibility of catalyst.

关 键 词：低共熔溶剂 多米诺反应 螺环吲哚衍生物 绿色合成 

分 类 号：O626[理学—有机化学]