含二氟甲基取代的吡唑酰胺类化合物的合成及杀菌活性  

Synthesis and Fungicidal Activity of Difluoromethy Substituted Carboxamide Derivatives

作　　者：刘婷婷[1] 倪芸[1] 钟良坤 黄红英 胡伟群 许天明 谭成侠[1] 

机构地区：[1]浙江工业大学化学工程学院,杭州310014 [2]中化蓝天集团有限公司浙江省化工研究院有限公,杭州310023

出　　处：《有机化学》2015年第2期422-427,共6页Chinese Journal of Organic Chemistry

基　　金：“十二五”国家科技支撑计划(No.2011BAE06B03-01);浙江省重点科技创新团队(No.2010R50018)资助项目~~

摘　　要：为了寻找高效安全的杀菌剂新品种和具有生物活性的新型先导化合物,根据活性亚结构拼接原理,将异噁唑和含氟基团引入到吡唑酰胺结构中,设计了13个未见文献报道的含异噁唑的二氟甲基吡唑酰胺类化合物,通过1H NMR,MS和HRMS对其结构进行了表征,并对目标产物进行了初步的生物活性测定.结果表明,在剂量为200 mg/L时,大部分化合物均表现出较高的杀菌活性.In the course of discovering novel fungicidal lead compounds with high activity and safety, 13 new difluoromethyl substituted carboxamide derivatives were designed and synthesized according to the principle of bioactive substructure combination. Their structures were confirmed by 1H NMR, MS and HRMS. The fungicidal activities of these compounds were evaluated. Preliminary bioassay showed that most of the title compounds showed good fungicidal activity at 200 mg/L.

关 键 词：异噁唑 吡唑酰胺 合成 杀菌活性 

分 类 号：TQ450.1[化学工程—农药化工] O626[理学—有机化学]