10例间充质干细胞治疗肝移植术后急性排斥反应的护理效果  

Nursing effect of acute rejection for 10 liver transplant patients with mesenchymal stem cells therapy

作　　者：褚静茹[1] 杨滢[1] 施明[1] 刘琼[1] 韩丹[1] 刘振文[1] 

机构地区：[1],解放军第三〇二医院肝胆外科二中心,北京100039

出　　处：《中华现代护理杂志》2015年第4期420-422,共3页Chinese Journal of Modern Nursing

基　　金：首都临床特色课题（Z111107058811069）;军队医学科技“十二五”科研重点项目（BWS11J075）

摘　　要：目的：研究间充质干细胞（ MSC ）在治疗肝移植术后急性排斥反应的护理方法及效果。方法回顾性分析2006—2012年行同种异体原位全肝移植（经典非转流）手术后出现急性排斥反应的10例患者,对输注MSC的过程进行规范护理和临床观察的分析。结果10例患者治疗前后SAS评分分别为（52.6±9.4）分和（40.3±8.2）分,治疗前后差异有统计学意义（t=3.118,P〈0.01）；患者术前每晚平均睡眠时间为（6.3±0.7）h,术后为（7.6±0.9）h,差异有统计学意义（t=-3.606,P〈0.01）；治疗前后10例患者血压有所改善,差异有统计学意义（P〈0.05）。10例患者自觉症状在输注完MSC后较入院时均有不同程度的改善,与治疗前比较差异有统计学意义（P〈0.05）。10例患者均无严重不良反应出现。结论重视和规范肝移植术后输注MSC的护理流程有利于改善患者的心理状态,减少不良反应,提高其治疗效果。Objective To investigate clinical nursing for acute liver allograft rejection with mesenchymal stem cells （ MSC ） therapy. Methods A total of 10 patients, who underwent the allogenic orthotopic liver transplantation in our center and suffered acute rejection, were enrolled during 2006 to 2012 and investigated by regression analysis. We regulated nursing procedure and observed clinical reaction during the procedure of MSC transfusion. Results The self-rating anxiety scale （ SAS） scores for the patients in pre- and post-MSC transfusion period were （52.6 ±9.4） and （40.3 ±8.2）, respectively （t=3.118,P〈0.01）. The sleep time were prolonged from pre-MSC transfusion （ 6. 3 ± 0. 7 ） hrs averagely to （ 7. 6 ± 0. 9 ） hrs （ t =-3.606,P 〈 0. 01）. The blood pressure also improved after transfusion （P 〈 0. 05）. In addition, the subjective symptoms were improved different degrees for all patients （P〈0. 05）, and no obvious side effects was found. Conclusions It benefits patients′ psychological state, side effects and treatment effect if attention and specification of nursing process were paid for the patients after liver transplantation with mesenchymal stem cell transfusion.

关 键 词：肝移植 护理 间充质干细胞 急性排斥反应 

分 类 号：R473.6[医药卫生—护理学]