淋巴细胞主动免疫治疗复发性流产的疗效观察  

Effectiveness of lymphocyte active immunotherapy in treating recurrent spontaneous abortion

作　　者：林慧[1] 王蕾[1] 段金良[1] 

机构地区：[1]解放军第181医院生殖医学部,桂林广西541002

出　　处：《中国优生与遗传杂志》2015年第3期59-60,62,共3页Chinese Journal of Birth Health & Heredity

基　　金：广西科学研究与技术开发计划项目(桂科攻1140003A-38)

摘　　要：目的观察采用丈夫或无关第三方外周血淋巴细胞治疗复发性流产的临床疗效,探讨封闭抗体与再次妊娠结局的关系。方法回顾性分析复发性流产且封闭抗体阴性的患者148例,采用淋巴细胞治疗,了解治疗后封闭抗体的变化及再次妊娠结局。结果 148例患者中,115例获妊娠成功,33例再次发生流产,妊娠成功率为77.7%(115/148);主动免疫治疗后118例患者进行复查,其中60例阳性,阳性率为50.8%(60/118),与治疗前比较,差异有统计学意义(P<0.05);封闭抗体阳性组、阴性组与未复查组的妊娠成功率分别为81.67%、74.13%、76.66%,差异无统计学意义(P>0.05)。结论淋巴细胞主动免疫治疗能提高封闭抗体阴性的复发性流产患者的再次妊娠成功率及封闭抗体的阳性率,是治疗复发性流产的一种有效方法。Objective：To observe the effectiveness of lymphocyte active immunotherapy in patients with recurrent spontaneous abortion（RSA）and investigate the relationship between blocking antibodies（BA）and the outcome of subsequent pregnancy.Methods：Retrospective reviews of the clinical literature on 148 RSA patients with negative BA,they were immunized with lymphocytes.The changes of BA after the treatment and the outcome of subsequent pregnancy were observed.Results：115 of 148 patients with the treatment were successfully conceived,33 cases happened recurrent abortion,pregnancy successful rate was 77.7%. In 118 cases reexamined after immunization,60 were positive,the positive rate was 50.8%（60/118）,compared with those before treatment,there was significant difference（P〈0.05）.The successful rate of pregnancy in positive BA,negative BA and non-examined BA is 81.67%,74.13%,76.66%,there was no significant difference（P〈0.05）.Conclusions：Lymphocyte active immunotherapy can improve the sucessful rate of subsequent pregnancy in BA-negative patients with RSA,and raise the positive rate of BA.It is an effective method of treating RSA.

关 键 词：淋巴细胞 免疫治疗 复发性流产 

分 类 号：R714.21[医药卫生—妇产科学]