保定地区新生儿先天性甲状腺功能低下症筛查回顾  

Review of Neonatal screening CH in Baoding area

作　　者：殷会芳[1] 

机构地区：[1]保定市妇幼保健院新筛室,河北071000

出　　处：《中国优生与遗传杂志》2015年第3期67-69,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的回顾性分析2008年-2012年间保定地区新生儿先天性甲状腺功能低下症(CH)的筛查情况及发病特征。方法以保定市区及各县出生的新生儿为筛查对象,采用时间分辨荧光分析法,测定新生儿足跟血干血斑中促甲状腺激素(TSH)的含量;结合血清学甲功结果综合诊断;并通过统计分析,了解该病的分布特征。结果 2008年-2012年共分娩活产儿744 983人,筛查新生儿504 642例,筛查覆盖率67.74%,确诊CH226例,CH发病率1/2233(44.78/10万),其中男121例,女105例,男女比例约为1.2∶1,筛查量和确诊量逐年递增,发病特点呈散发性分布。结论 1.随着人们对新生儿筛查认知度的提高,筛查量逐年递增。2.新生儿CH筛查是临床早发现该病的重要手段,为早诊断,早治疗,避免患儿体格和智能发育障碍提供科学依据。3.未发现家族性甲低发病。Objective：This article is to review and analyze the screening situation and distribution characteristic of congenital hypothyroidism（CH）of Neonates in Baoding area during 2008 to 2012.Methods：The distribution feature is studied through statistical analysis combined with the comprehensive diagnosis of the test results of TSH,T4 and FT4 level in serum. Testing the concentration of TSH on the dried blood spot on the filter paper sampled from the Neonates in Baoding. Results：504 642 neonates were screened during 2008-2012,taking up 67.7% of the total amount,226（male 121,female 105）were diagnosed with CH. Conclusion：With popularization of prevention and healthcare and enhancement of spread,the understanding of neonatal screening for people is increasingly rising. It is fact that neonatal screening is an importance way to detect CH in clinical,which can provide scientific evidence for early diagnosis,treatment and prevent children from development of disable brain and body. Also,CH in familial was not found.

关 键 词：新生儿 先天性甲低 发病特点 

分 类 号：R722.1[医药卫生—儿科]