两种不同麻醉方式对胆囊切除术患者炎症细胞因子的影响  

Effect of Two Different Anesthesia Methods on Inflammatory Cytokines in Patients Undergoing Gallbladder Resection

作　　者：杨柳[1] 

机构地区：[1]湖南省常德市第一人民医院麻醉科,常德415000

出　　处：《中国医药导刊》2015年第2期172-174,共3页Chinese Journal of Medicinal Guide

摘　　要：目的:探讨两种不同麻醉方法对胆囊切除术患者炎性细胞因子的影响。方法:将164例行胆囊切除术患者随机分为全凭静脉麻醉组(Q组,n=82)和静吸复合麻醉组(J组,n=82),分别记录两组患者在麻醉前(0h)、术后2h、4h、8h的SBP、DBP、MAP、HR和Sp O2的变化情况,并采用用酶联免疫吸附测量法(ELISA)在相同时间点检测细胞因子CRP、IL-6和IL-10水平。结果:两组患者在各时间点SBP、DBP、MAP,HR和Sp O2无显著性差异(P>0.05)。两组血清CRP、IL-6和IL-1O水平在术后2h,4h,8h均较麻醉前均有显著增加,术后8h Q组血清CRP、IL-6水平显著低于J组(P<0.05),而IL-10水平在Q组4h、8h均明显高于J组(P<0.05)。结论:全凭静脉麻醉可以通过减少炎症细胞因子和增强抗炎细胞因子来减轻手术应激所致的炎症反应,有助于胆囊切除术患者的预后。Objective： To investigate the effect of two different anesthesia methods on inflammatory cytokines in patients of gallbladder resection.Methods：164 patients were randomly divided into the total intravenous anesthesia group（group Q,n=82） and inhalation anesthesia group（group J,n=82）.SBP,DBP,MAP,HR and SpO2 were recorded before anesthesia（0h） and 2h,4h,of 8h after the operation in patients of two group.The expression of CRP,IL-6 and IL-10 levels were detected using enzyme-linked immunosorbent method（ELISA） in patients of two groups in the same time points.Results：There was no significant difference in SBP,DBP,MAP,HR and SpO2 at each time point in patients of two groups（P〈0.05）.Serum CRP,IL-6 and IL-10 levels of two groups after 2h,4h,8h of anesthesia were significantly increased compared with those before anesthesia.Serum CRP,IL-6 level of Q group was lower than that in J group after 8 hours of anesthesia（P〈0.05）,and IL-10 level in Q group were significantly higher than those in J group after 4h,8h of anesthesia（P〈0.05）.Conclusion：Total intravenous anesthesia can reduce the inflammatory response caused by operation by reducing the inflammatory cytokines and increasing anti-inflammatory cytokines.The prognosis is helpful for patients undergoing cholecystectomy.

关 键 词：全凭静脉麻醉 胆囊切除术 细胞因子 白细胞介素-6 

分 类 号：R614[医药卫生—麻醉学]