苄星青霉素联合头孢曲松钠对早期梅毒患者皮损及血液免疫指标的影响观察  

Influence of benzathine benzylpenicillin combined with ceftriaxone sodium for the skin lesion and blood immune indexes of patients with early syphilis

作　　者：鞠小玲 杜坤[1] 程丰[2] 苏江维[1] 

机构地区：[1]鄂州市中心医院皮肤科,湖北鄂州436000 [2]鄂州市中心医院检验科,湖北鄂州436000

出　　处：《中国性科学》2015年第2期53-56,共4页Chinese Journal of Human Sexuality

摘　　要：目的:观察苄星青霉素联合头孢曲松钠对早期梅毒患者皮损及血液免疫指标的影响程度。方法:选取2011年3月至2013年8月于本院进行诊治的60例早期梅毒患者为研究对象,将60例患者随机分为对照组(苄星青霉素组)30例和观察组(苄星青霉素联合头孢曲松钠组)30例,然后将两组患者治疗前和治疗后1个月、3个月时的红细胞免疫、皮损及外周血T淋巴细胞亚群指标进行检测与比较。结果:观察组治疗后1个月及3个月时的红细胞免疫及外周血CD3+、CD4+、CD4/CD8均高于对照组,而CD8+均低于对照组,皮损CD3+、CD4+、CD4/CD8均低于对照组,而CD8+均高于对照组,P<0.05,均有显著性差异。结论:苄星青霉素联合头孢曲松钠对早期梅毒患者皮损及血液免疫指标的影响较大,对患者的治疗效果好于单用苄星青霉素。Objectives： To observe the influence of benzathine benzylpenicillin combined with ceftriaxone sodium for the skin lesion and blood immune indexes of patients with early syphilis. Methods： 60 patients with early syphilis in our hospital from March 2011 to August 2013 were selected and randomly divided into control group（ benzathine benzylpenicillin group,30 cases） and observation group（ benzathine benzylpenicillin combined with ceftriaxone sodium group,30 cases）. The erythrocyte immune,skin lesion and peripheral blood T lymphocyte subsets of two groups before the treatment and at first and third month after the treatment were detected and compared.Results： The erythrocyte immune and peripheral blood CD3 ＋,CD4 ＋,CD4 / CD8 of observation group at first and third month after the treatment were all higher than those of control group,while CD8 ＋ were lower than those of control group,and skin lesion CD3 ＋,CD4 ＋ and CD4 / CD8 were lower than those of control group,CD8 ＋ were higher than those of control group,with significant differences（ all P〈0. 05）. Conclusion： The influence of benzathine benzylpenicillin combined with ceftriaxone sodium for the skin lesion and blood immune indexes of patients with early syphilis is great,and its treatment effect for the patients is better than that of only benzathine benzylpenicillin.

关 键 词：苄星青霉素 头孢曲松钠 早期梅毒 皮损 血液 免疫指标 

分 类 号：R759.1[医药卫生—皮肤病学与性病学]