正常和骨质疏松大鼠股骨介电特性研究  

Study on dielectric properties of femurs from normal and osteoporosis rats

作　　者：郑凯中[1] 陶峰[2] 杨旻[3] 

机构地区：[1]第四军医大学学员旅,西安710032 [2]第四军医大学生物医学工程学院,西安710032 [3]第四军医大学西京医院骨科,西安710032

出　　处：《医疗卫生装备》2015年第2期9-13,共5页Chinese Medical Equipment Journal

基　　金：国家自然科学基金资助项目(50937005;61102029)

摘　　要：目的 ：探索正常大鼠与糖尿病骨质疏松大鼠股骨介电特性之间的差异。方法 ：2月龄雄性SD大鼠随机分为2组（8只/组）：对照组（正常大鼠）和实验组（糖尿病大鼠）。经过8周后在恒温（37℃）条件下,测量股骨介电特性（10~106Hz）,并进行显微结构与形态学分析。结果 ：对照组的电导率均显著大于糖尿病组（P〈0.01）;在低频段（10、100、1 000 Hz）对照组的介电常数显著高于糖尿病组（P〈0.01）,而当频率进一步上升时,2组之间不存在显著性差异。结论 ：大鼠股骨电导率变化与骨质疏松显著相关。Objective To explore the difference of femur dielectric properties between normal rats and Diabetic osteoporosis rats. Methods A control group and an experiment group were formed with eight male Sprague-Dawley rats two months old in each, and the former involved normal rats and the latter had diabetic ones. Then at the constant temperature of 37 ℃, the femur dielectric properties with the frequency range from 10 to 106 Hz were measured eight weeks later, and the analysis on microstructure and morphology was carried out. Results The conductivity of the control group was significantly higher than that of the experiment group, with P0.01. Within the low frequency range of 10 Hz,100 Hz and 1 000 Hz, the dielectric constant of the control group was significantly higher than that of the experiment group with P 0.01, while had no statistical difference with the latter as the frequency increased. Conclusion The conductivity of rat femur is significantly correlated with osteoporosis.

关 键 词：大鼠 糖尿病骨质疏松 介电特性 微观结构 

分 类 号：R580[医药卫生—内分泌]