FAT10在乳腺癌中的表达及其临床病理意义  

The expression and clinical-pathological significance of FAT10 in breast cancer

作　　者：张春阳[1] 王娟[1] 王星[2] 王翠芳[2] 孙洁[2] 

机构地区：[1]沈阳医学院附属中心医院普外科,辽宁沈阳110024 [2]沈阳医学院附属中心医院病理科,辽宁沈阳110024

出　　处：《现代预防医学》2015年第6期1009-1011,1022,共4页Modern Preventive Medicine

基　　金：社区医学教育对全科医学生综合能力培养的初探(辽宁省教育厅2009-85)

摘　　要：目的探讨双泛素(human leukocyte antigen F-associated transcript 10,FAT10)在基底细胞样及非基底细胞样乳腺癌中的表达情况及其临床病理意义。方法应用免疫组化方法,检测155例浸润性乳腺癌及癌旁组织中FAT10的表达情况,并分析其表达与乳腺癌患者临床病理因素及基因分型之间的关系。结果 FAT10在浸润性乳腺癌中的阳性表达率为55.58%,明显高于癌旁组织(21.29%)(P<0.05)。FAT10的表达与乳腺癌的核分级、淋巴结转移情况密切相关。基底细胞样乳腺癌FAT10的阳性表达率高于非基底细胞样乳腺癌(P<0.05)。结论 FAT10的表达与乳腺癌的恶性程度及侵袭转移密切相关,基底细胞样乳腺癌更易于表达FAT10。Objective The aim of the study was to determine the expression and clinical-pathological significance of human leukocyte antigen F-associated transcript 10（FAT10） in basal-like and non-basal-like breast cancers. Methods FAT10 expression in 155 patients with invasive breast cancer and in their para-carcinoma tissues was measured by immunohistochemistry.The relationship between FAT10 expression and clinical-pathological factors for and genotype of breast cancer were analyzed.Results The positive rate of FAT10 expression in invasive breast cancer was 55.58%, significantly higher than that in the para-carcinoma tissues（21.29%）（P〈0.05）. FAT10 expression was closely associated with nuclei classification and lymphatic spread of breast cancer. The positive rate of FAT10 expression in basal-like breast cancer was higher than that of non-basal-like breast cancer（P〈0.05）. Conclusion FAT10 expression is closely associated with severity and invasive metastasis of breast cancer.Overexpression of FAT10 is more likely to occure in basal-like breast cancer.

关 键 词：乳腺癌 基底细胞样乳腺癌 FAT10 

分 类 号：R319[医药卫生—基础医学] R737.9