西安地区呼吸道疾病病毒病原谱分析  

Viral Pathogen Spectrum Analysis of Respiratory Tract Diseases in Xi'an Area

作　　者：张蕾[1] 许晶[1] 史伟[1] 王丽[1] 马萍[1] 徐艺[1] 郑媛[1] 邓慧玲[2] 夏静[3] 刘洋[4] 薛威[5] 王敬军[1] 余鹏博[1] 

机构地区：[1]陕西省疾病预防控制中心病毒室,陕西西安710054 [2]西安市儿童医院感染科,陕西西安710003 [3]解放军第323医院感控科,陕西西安710000 [4]陕西省人民医院,陕西西安710068 [5]西安交通大学医学院公共卫生学院,陕西西安710061

出　　处：《现代预防医学》2015年第6期1099-1103,共5页Modern Preventive Medicine

基　　金："十二五"国家科技重大专项"艾滋病和病毒性肝炎等重大传染病防治"(2013ZX10004202-001-002)

摘　　要：目的分析陕西省西安地区呼吸道疾病病毒病原谱分布情况。方法收集西安市6家医院的呼吸道感染病例971例,采集咽拭子标本进行16种型别呼吸道病毒核酸检测。结果 971份标本的检出率为32.65%(317/971),检出16种病毒。多种呼吸道病毒在冬季高发,各人群检出率(χ2=31.566)、各年龄组检出率(χ2=25.312)均存在统计学差异(P<0.05),主要集中在15岁以下散居儿童。住院病例检出率(41.52%)与门诊病例(27.82%)有统计学差异(χ2=18.906,P<0.05),两者的混合感染比例也存在统计学差异(χ2=10.718,P<0.05)。上呼吸道感染以腺病毒居多,下呼吸道感染以呼吸道合胞病毒居多。结论西安地区的呼吸道病毒性疾病有16种型别被检出,冬春季高发,流感病毒、呼吸道合胞病毒和腺病毒所占比例较高,儿童为呼吸道病毒感染的高发人群,混合感染多为小年龄组的住院病例。Objective This study aimed to analyze the viral pathogen spectrum of respiratory tract diseases in Xi＇an, Shaanxi Province. Methods 971 cases of respiratory infections were collected from six hospitals in Xi＇an from 2009 to 2013. ABT 9＋7Respiratory Multiple PCR kit was used to detect specific nucleotide segments of 16 respiratory viruses. Results All samples were tested, and 32.65% was positive（317/971）. 16 types of virus were detected. Most viruses were prevalent in winter. Positve rate vaired among cohort（χ^2=31.566） and between age groups（χ^2=25.312）, and the age group with the most types of respiratory viruses was the group of 15 years old, especially among scattered children. The positive rate was higher among hospitalized cases（41.52%）than outpatient cases（27.82%, χ^2=18.906）. The rate of co-infection between hospitalized cases and outpatients also significantly different（χ^2=10.718, P〈0.05）. Adenovirus（ADV） was detected mainly in upper respiratory infections and respiratory syncytial virus（RSV） was tested mainly from lower respiratory infections. Conclusion We detected 16 types of respiratory viruses. Influenza virus（IFV）, RSV and ADV were the main pathogens leading to respiratory infections in Xi＇an. Children were the susceptible population for respiratory diseases. Co-infections occurred mainly in hospitalized patients of young age.

关 键 词：呼吸道疾病 病原谱 西安 

分 类 号：R183.3[医药卫生—流行病学]