全自动双溶出在线稀释和检测系统的时序管理  

Scheduling of Double-bath Automatic Dissolution System with On-line Dilution and Testing

作　　者：刘茜[1] 宋冬梅[1] 陈阳[1] 杨永健[1] 史丽芳 

机构地区：[1]上海市食品药品检验所,上海201203 [2]北京清研思创科学仪器有限公司,北京100029

出　　处：《中国医药工业杂志》2015年第3期312-315,共4页Chinese Journal of Pharmaceuticals

摘　　要：建立了一套同时支持两套溶出仪的全自动溶出、在线稀释和检测系统,重点研究了两套溶出仪、双取样泵、双补液系统、稀释平台、UV进样系统和UV检测工作时的时序调度,确保整套方案在符合药典要求的情况下,各子系统之间不会发生冲突,并达到效率最优的目的。系统采用盐酸氨溴索片进行验证,在30 min内采样5次,共60个样品,并自动协调稀释、进样和检测等过程,实验表明,采用该时序调度的方案可确保实验结果符合要求,并且在现有方法上将效率提高了100%以上。A double-bath automatic dissolution system with on-line dilution and testing was built. The time scheduling to coordinate the double baths, double collection pumps, double loss replacement subsystems, dilution workstation, UV injection subsystem and UV detection was studied to make sure the time points of sampling, dilution and injection were controlled precisely. The scheduling was optimized to improve the efficiency and avoid the conflicts among the collection, the sample dilution and measurement time. The system was validated by the ambroxol hydrochloride test, which collected 60 samples at 5 time points in 30 min, and coordinated the dilution, injection and measurement procedures automatically. The results showed that the efficiency could be improved by more than 100% while the result was promised with well-designed time scheduling.

关 键 词：全自动溶出 双溶出仪 时序调度 盐酸氨溴索 

分 类 号：R917[医药卫生—药物分析学]