猪防御素的研究进展及其在饲料中的应用  

Research Progress on Porcine Defensin and Its Application to Feed Industry

作　　者：王丹玉[1,2] 彭子欣[1,2,3] 王洪彬[1,2] 王安如[1,2,3] 

机构地区：[1]北京大北农科技集团股份有限公司,北京100080 [2]饲用微生物工程国家重点实验室,北京100192 [3]北京市饲料安全生物调控工程技术研究中心,北京100192

出　　处：《中国畜牧杂志》2015年第5期86-90,共5页Chinese Journal of Animal Science

基　　金：国家国际科技合作专项资助(2011DFA32330);基因芯片技术在饲料高效利用与安全调控上的应用研究

摘　　要：防御素是一类富合半胱氨酸的阳离子活性多肽,是动物先天性免疫防御系统的重要组成部分,防御素在动物组织细胞中广泛表达,是宿主抵抗外界病原微生物入侵的第一道防线。防御素具有的抗菌谱广、抗菌机制特殊、不易产生耐药性、残留低、对动物自身正常细胞没有伤害等特点,使防御素成为替代抗生素的最佳候选之一,未来将在畜禽生产中具有广阔的应用前景。本文主要对猪防御素基因的特点及其在动物组织中的表达谱、防御素在猪体内的表达调控特性、基因工程菌以及防御素在饲料业中的应用等方面进行阐述。Defensins are a family of endogenous cationic peptides produced widely in mammalian tissue cells, and play an important role in the innate immune systems and provide the first defensive line for the hosts against pathogenic microorganism infections. Defensins exhibit broad antimicrobial spectrums, special antibacterial mechanism, difficulty in developing drug-resistant bacteria, less residue, and no or less harm to host cells. Therefore, defensins have the potential to be substitutes for traditional antibiotics as feed additive to promote animal growth and have broad application prospects in livestock and poultry production. This review provided gives a detailed elaboration to porcine defensin about their genetic characteristics, tissue expression profile, expression and regulation in porcine, genetically engineered bacterium, and its application in feed industry.

关 键 词：猪防御素 表达调控 基因工程菌 饲料添加剂 

分 类 号：S828.5[农业科学—畜牧学]