拉米夫定致周围神经病  

Peripheral neuropathy induced by lamivudine

作　　者：赵晓卫[1] 陈红利[1] 徐灿丽[1] 

机构地区：[1]首都医科大学附属北京地坛医院门诊,100015

出　　处：《药物不良反应杂志》2015年第1期54-54,共1页Adverse Drug Reactions Journal

摘　　要：1例56岁女性患者因慢性乙型肝炎服用拉米夫定100 mg,1次/d.3年后患者出现四肢麻木.肌电图检查示感觉神经传导速度减慢.给予维生素B1、甲钴胺治疗2个月,未见好转.停用拉米夫定,改为阿德福韦酯10 mg,1次/d口服.2个月后,患者四肢麻木症状明显好转.A 56-year-old female patient with chronic hepatitis B was treated with lamivudine 100 mg once daily.Three years later,the patient developed numbness of extremities.Electromyography showed slower sensory nerve conduction velocity.She was given treatment with vitamin B1 and mecobalamin for two months,but her symptoms was not improved.Lamivudine was discontinued and therefore switched to adefovir dipivoxil 100 mg once daily.Two months later,her symptom of numbness improved significantly.

关 键 词：拉米夫定 周围神经系统疾病 

分 类 号：R512.62[医药卫生—内科学]