奥沙利铂致过敏反应的文献分析  

Oxaliplatin-induced Allergic Reactions: Literature Analysis

作　　者：苏圆[1] 刘贤铭[1] 

机构地区：[1]江苏省肿瘤医院药剂科,南京210009

出　　处：《中国医院用药评价与分析》2015年第1期131-134,共4页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:探讨奥沙利铂致过敏反应的特点,为临床安全用药提供参考。方法:检索国内医药期刊中有关奥沙利铂致过敏反应的文献报道,从患者年龄与性别、化疗方案、过敏反应程度、过敏反应发生时间及临床表现等方面进行统计分析。结果:共检索到奥沙利铂致过敏反应相关文献20篇,涉及病例55例。50例(占90.91%)患者在用药30 min内出现过敏症状;发生过敏反应的中位周期为第5周期,中位累积剂量为540 mg/m2;多数为Ⅱ度过敏反应(32例,占58.18%);临床表现以皮肤及其附件损害(29例次,占总计104例次的27.88%)、呼吸系统损害(28例次,占总计104例次的26.92%)最为常见。结论:奥沙利铂致过敏反应可发生于化疗的任一周期,故临床应用奥沙利铂时应加强监测,密切观察,一旦出现过敏反应应立即处理。OBJECTIVE：To explore the characteristics of the allergic reactions induced by Oxaliplatin for clinical reference of safe medication .METHODS： The reports of oxaliplatin-induced allergic reactions retrieved in domestic medicinal journals were statistically analyzed in respect of patients＆#’age and sex , chemotherapy regimen , degree , onset and the clinical manifestations etc of the allergic reaction .RESULTS：A total of 20 papers involving 55 allergic cases induced by oxaliplatin were retrieved , with allergic reaction appeared in 50 （ 90.91%） within 30 min after drug administration;on average , the allergic reactions occurred in the fifth cycle of oxaliplatin-containing therapy with median cumulative dose of 540 mg/m2; most allergic reactions were defined as degree Ⅱ（ 32 cases, 58.18%） . Lesions of skin and its appendants （29/104 episodes, 27.88%） and respiratory symptoms （28/104, 26.92%） were the most common clinical manifestation .CONCLUSIONS： Allergic reactions induced by oxaliplatin may occur in any one cycle of chemotherapy;hence , monitoring on oxaliplatin-induced allergic reactions should be strengthened so as to take immediate action in case of allergic reaction .

关 键 词：奥沙利铂 过敏反应 文献分析 

分 类 号：R969.3[医药卫生—药理学]