噬菌体及其治疗细菌感染的研究进展  

Research Progress on Bacteriophage and the Therapy in Bacterial Infection

作　　者：朱育玮 李玉保[1] 王守荣[1] 吴伟胜[1] 夏光州 肖传刚 

机构地区：[1]聊城大学农学院,聊城252059 [2]潍坊市滨海区农林水利局,潍坊261000 [3]海阳市畜牧局,烟台265100

出　　处：《中国畜牧兽医》2015年第3期769-773,共5页China Animal Husbandry & Veterinary Medicine

基　　金：国家自然科学基金(31101787);山东省自然科学基金(ZR2010CM035)

摘　　要：噬菌体在其发现之初便被用于细菌感染的治疗。然而,随着抗生素时代的到来,噬菌体的研究便被忽略。近半个世纪以来,耐药菌株不断出现,抗生素治疗面临巨大挑战。噬菌体作为细菌的天然杀手,对细菌性疾病有很好的治疗效果,其研究价值逐渐引起科学家们的重视。作者对噬菌体、噬菌体治疗细菌感染的应用、噬菌体制剂、噬菌体治疗局限性及发展趋势等方面作一简要概述。At the time of bacteriophage＇s discovery,bacteriophage therapy was regarded as a possible treatment method against bacterial infection.However,it was abandoned with the arrival of the antibiotic era.Nearly half a century,the ongoing evolution of bacterial multidrug-resistance had recently motivated the scientists to reevaluate bacteriophage therapy for bacterial infections.This paper summarized bacteriophage,the application of bacteriophage therapy of bacterial infection,bacteriophage preparation,the deficiency of bacteriophage therapy and development trend and prospects of bacteriophage therapy.

关 键 词：噬菌体 细菌感染 噬菌体治疗 噬菌体制剂 裂解酶 

分 类 号：R515[医药卫生—内科学]