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机构地区:[1]菏泽市立医院妇产科,274000 [2]菏泽市立医院检验科,274000
出 处:《国际免疫学杂志》2015年第2期134-137,共4页International Journal of Immunology
摘 要:目的探讨宫颈癌根治术患者的心理健康状态对其免疫学相关指标的影响。方法将2009年5月至2013年5月期间我院收治的156例接受宫颈癌根治术的患者按照数字表法将患者随机分为观察组和对照组各78例。观察组患者在行常规护理的基础上,根据患者的心理特征给予相关干预措施,而对照组患者仅进行常规护理;记录两组患者心理特点以及免疫学相关指标变化。结果干预前,两组患者的SDS、SAS评分和免疫学相关指标之间无统计学差异(P〉0.05);干预后,对照组患者的SDS和SAS评分较干预前无明显改善(P〉0.05),而观察组术前抑郁自评量表(SDS)和焦虑自评量表(SAS)评分均低于干预前,组内比较差异具有统计学意义(均P〈0。01);同时,观察组患者的SDS和SAS评分均低于对照组(均P〈0.01);此外,两组患者的CD3^+、CD4^+、CD8^+、CD4^+/CD8^+和肿瘤坏死因子(TNF)-α水平与干预前比较均有明显改善(均P〈0.01);同时,观察组患者的CD3^+和CD4^+水平均显著高于对照组,而CD8^+和TNF-α水平显著低于对照组,两组间差异组内比较差异具有统计学意义(均P〈0.01)。结论对宫颈癌根治术患者进行良好的护理干预,有助于缓解患者的抑郁、焦虑等不良心理状态,更为重要的是能够提高患者的免疫力,进而能够使患者预后改善显著,值得临床推广应用。[ Abstract] Objective To explore the effect of relieving anxiety'and depression on the immunity indexes with cervical patients after radical hysterectomy. Methods 156 cases of cervical cancer patients after radical hysterectomy who got medical treatment at our hospital from May 2009 to May 2013 were randomly divided into observation group and control group, 78 patients in each group, patients in control group received conventional nursing, while patients in observation group were cured with psychological nursing interventions based on their psychological trait. The psychological characteristics and immune indices of these two groups were detected. Results Before the intervention, SDS, SAS and immunology indexes showed no significant difference between these two groups ( P 〉 0.05 ) ; After the intervention, the SDS and SAS scores of observation group were significantly lower ( P 〈 0.01 ) ; meanwhile there were no obvious change in the control group ( P 〉 0.05 ) ; Two scores in observation group were significantly lower than those in control group ( P 〈0. 01 ) ; Moreover, T lym- phocyte subsets ( CD3^+, CD4^+, CD8 ^+, CD4^+ +/CD8^+ ) and the level of TNF-α were improved distinctly after the intervention ( P 〈 0.01 ). And the CD3 ^+ T and CD4^+ T were significantly higher than those in the controls ( P 〈 0. 01 ) ; T lymphocyte subsets CD8 ^+ T and TNF-α show obviously lower in observation group ( P 〈0. 01 ). Conclusion Comprehensive nursing intervention could improve cervical cancer patients' depression and anxiety mental health, enhance their immunity function, improve the prognosis, and obvious treating effect.
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