玻璃化冻融胚胎移植妊娠结局的影响因素分析  

Factors influencing the outcome of vitrification-thawed embryo transfer

作　　者：张静[1] 吕睿[1] 吕永焕[1] 宋学茹[1] 赵晓徽[1] 白晓红[1] 

机构地区：[1]天津医科大学总医院妇产科生殖中心,300052

出　　处：《中国计划生育学杂志》2015年第3期178-181,共4页Chinese Journal of Family Planning

摘　　要：目的:探讨玻璃化冻融胚胎移植妊娠结局的影响因素。方法:对接受玻璃化冻融胚胎移植患者的247个周期进行回顾性分析,根据患者的临床结局分为妊娠组(112例)和非妊娠组(135例)。对年龄、不孕原因、受精方式、冻融胚胎移植次数、移植胚胎数目、胚胎质量、子宫内膜厚度、子宫内膜准备方案、冻胚时间等9个可能影响因素进行分析。结果:妊娠组与非妊娠组的冻胚时间和子宫内膜厚度均有统计学差异(χ2=8.703,P=0.003;χ2=2.838,P=0.009),logistic多因素回归分析结果显示冻胚时间和子宫内膜厚度与妊娠结局有关。结论:玻璃化冻融胚胎移植受精后第3天冻胚比第2天冻胚的胚胎临床妊娠率更高;在一定范围内,移植日子宫内膜厚度>11.0mm比≤11.0mm患者的妊娠率更高。Objective：To explore the influencing factors of the outcome of the vitrification-thawed embryo transfer.Methods：A retrospective analysis was conducted on the related data of 247 cases who underwent the vitrification-thawed embryo transfer.Patients were divided into pregnancy group（n=112）and non-pregnancy group（n=135）.Nine possible influencing factors including age,cause of infertility,fertilization method,frozen-thawed embryo transfer cycles,embryo number transferred,embryo quality,endometrial thickness,endometrial preparation program,cryopreservation timing were analyzed.Results：The differences of the cryopreservation timing（χ^2=8.703,P=0.003）and the endometrial thickness（χ^2=2.838,P=0.009）between the pregnancy group and the non-pregnancy group were significant.Logistic regression analysis results showed that the cryopreservation timing and the endometrial thickness were related to pregnancy outcome.Conclusion：In vitrification-thawed embryo transfer,the clinical pregnancy rate of D3 embryo is higher than D2 one,and within a certain range,the clinical pregnancy rates of women with more than 11.0 mm of the endometrial thickness are higher than those with not more than 11.0mm of the endometrial thickness.

关 键 词：玻璃化冻融胚胎 影响因素 logisic模型 多因素回归分析 辅助生殖技术 

分 类 号：R714.8[医药卫生—妇产科学]