肺癌患者肺部感染病原菌分布与耐药性分析  

Distribution and drug resistance of pathogens causing pulmonary infections in lung cancer patients

作　　者：骆松梅[1] 纪建松[1] 朱超[1] 蒋晓梅[1] 

机构地区：[1]丽水市中心医院,浙江丽水323000

出　　处：《中华医院感染学杂志》2015年第5期987-989,共3页Chinese Journal of Nosocomiology

基　　金：国家卫计委科研基金资助项目(W200913X022)

摘　　要：目的了解医院肺癌患者发生肺部感染病原菌种类以及药敏性,为其临床抗菌药物使用提供合理依据。方法回顾性分析医院2010年1月-2012年10月304例肺癌住院患者临床资料,对发生肺部感染患者送检标本检出的病原菌使用Biomerivex公司的微生物鉴定仪进行鉴定,药敏试验采用K-B扩散法,对相关信息进行数据录入和统计分析。结果共86例肺癌患者发生肺部感染,感染率28.3%;共分离出病原菌32株,以革兰阴性菌为主,占81.3%,包括副流感嗜血菌、肺炎克雷伯菌、铜绿假单胞菌、大肠埃希菌、鲍氏不动杆菌;其次为革兰阳性球菌,占15.6%,为表皮葡萄球菌、屎肠球菌、人葡萄球菌;真菌占3.1%,为白色假丝酵母菌;其他占6.3%。结论肺癌患者发生肺部感染病原菌以革兰阴性菌为主,其病原菌的研究可为肺癌伴肺部感染患者临床合理使用抗菌药物提供依据。OBJECTIVE To investigate the distribution and drug susceptibility of pathogens causing pulmonary in‐fections in the lung cancer patients so as to provide guidance for the clinical use of antibiotics .METHODS The clini‐cal data of 304 lung cancer patients who were hospitalized from Jan 2010 to Oct 2012 were retrospectively ana‐lyzed ,then the pathogens that were cultured from the submitted specimens collected from the participants with pulmonary infections were identified by using the microorganism identification system of Biomerivex ,the drug sus‐ceptibility testing was performed with the use of K‐B method ,and the relevant information was input to conduct the statistical analysis .RESULTS The pulmonary infections occurred in 86 lung cancer patients ,with the infection rate of 28 .3% .A total of 32 strains of pathogens have been isolated ,of which 81 .3% were the gram‐negative bacteria ,15 .6% were the gram‐positive cocci ,3 .1% were the fungi ,and 6 .3% were others ;the Haemophilus parainfluenzae,Klebsiellapneumoniae,Pseudomonasaeruginosa,Escherichiacoli,andAcinetobacterbauman‐nii were the species of the gram‐negative bacteria ;the Staphylococcus epidermidis ,Enterococcus f aecium ,and Staphylococcus hominis were the species of gram‐positive cocci ;the Candida albicans was the species of fungi . CONCLUSION The gram‐negative bacteria are dominant among the pathogens causing the pulmonary infections in the lung cancer patients ,and the study of the pathogens can provide guidance for reasonable clinical use of antibi‐otics for the lung cancer patients complicated with pulmonary infections .

关 键 词：肺癌 肺部感染 病原菌 合理用药 

分 类 号：R378[医药卫生—病原生物学]