利奈唑胺与替考拉宁序贯治疗革兰阳性球菌重症肺炎疗效分析  

Clinical efficacies of linezolid and teicoplanin in sequential treatment of severe pneumonia caused by gram-positive cocci

作　　者：王东升[1] 牟吉 王斌梁[1] 李宁[1] 柯欣[2] 

机构地区：[1]台州市第一人民医院呼吸内科,浙江台州318020 [2]台州市第一人民医院ICU,浙江台州318020

出　　处：《中华医院感染学杂志》2015年第5期1050-1052,共3页Chinese Journal of Nosocomiology

基　　金：浙江省卫生厅基金资助项目(2010B126)

摘　　要：目的调查利奈唑胺与替考拉宁序贯治疗革兰阳性球菌重症肺炎的临床疗效和安全性。方法选择呼吸内科2009年2月-2012年2月收治的67例革兰阳性球菌重症肺炎患者,先给予利奈唑胺静脉滴注治疗7d,然后给予替考拉宁静脉滴注序贯治疗7d,分别于治疗前后观察患者的临床症状、体征及不良反应,并分析治疗的临床疗效和细菌清除率。结果利奈唑胺和替考拉宁序贯治疗革兰阳性球菌重症肺炎的总有效率为89.5%、细菌清除率为89.6%;其中对耐甲氧西林金黄色葡萄球菌感染引起的重症肺炎总有效率为86.2%、细菌清除率为82.8%;治疗期间所有患者均未出现严重肝肾功能损害和血小板水平降低等常见不良反应。结论利奈唑胺与替考拉宁序贯治疗革兰阳性球菌重症肺炎临床疗效确切不良反应少,值得临床推广和普及。OBJECTIVE To observe the clinical efficacies and safety of linezolid and teicoplanin in sequential treat‐ment of severe pneumonia caused gram‐positive cocci .METHODS A total of 67 patients with severe pneumonia caused by gram‐positive cocci ,who were treated in the respiratory medicine department from Feb 2009 to Feb 2012 ,were enrolled in the study ,then the participants were firstly treated with intravenous infusion of linezolid for 7 days and then were given the intravenous infusion of teicoplanin for sequential treatment for 7 days;the clini‐cal symptoms ,signs ,and adverse reactions were observed before and after the treatment ,and the clinical efficacies and bacterial clearance rate were analyzed .RESULTS The total effective rate of sequential treatment of severe pneu‐monia caused by gram‐positive cocci with linezolid and teicoplanin was 89 .5% ,the bacterial clearance rate was 89 .6% ;the total effective rate of the treatment of severe pneumonia caused by methicillin‐resistant Staphylococcus aureus infection was 86 .2% ,and the bacterial clearance rate was 82 .8% .The common adverse reactions such as the severe liver and kidney dysfunction and reduced platelet level did not occur in any of the patients during the treatment .CONCLUSION Linezolid in combination with teicoplanin can achieve exact clinical effect on sequential treatment of severe pneumonia caused by gram‐positive cocci ,and it has less adverse reactions and is worthy to be promoted in the hospital .

关 键 词：重症肺炎 革兰阳性球菌 利奈唑胺 替考拉宁 

分 类 号：R978.1[医药卫生—药品]