左氧氟沙星与头孢他啶治疗晚期泌尿系肿瘤患者感染的临床效果分析  

Clinical effect of levofloxacin combined with ceftazidime on treatment of infections in patients with advanced urinary tract tumors

作　　者：梁骏[1] 杨惠雯[1] 刘孝华[1] 张银高[1] 

机构地区：[1]湖北民族学院附属民大医院泌尿外科,湖北恩施445000

出　　处：《中华医院感染学杂志》2015年第5期1056-1058,共3页Chinese Journal of Nosocomiology

基　　金：湖北省卫生厅科研基金资助项目(JX4B55)

摘　　要：目的探讨分析左氧氟沙星联合头孢他啶治疗晚期泌尿系肿瘤患者感染的效果,总结临床经验,为晚期泌尿系肿瘤感染患者的治疗提供理论依据。方法随机抽取医院2006年8月-2014年2月120例晚期泌尿系统肿瘤感染患者作为研究对象,将其分为两组,每组各60例,两组患者的各项资料差异无统计学意义,具有可比性;A组给予左氧氟沙星治疗,B组给予左氧氟沙星联合头孢他啶治疗,治疗周期均14d,比较两组患者抗感染的疗效及不良反应的发生率。结果 A组患者痊愈22例、显效28例、进步7例,分别占36.7%、46.7%、11.7%,总有效率83.3%,有3例患者治疗无效;B组患者痊愈25例、显效32例、进步2例,分别占41.7%、53.3%、3.3%,总有效率95.0%,有1例患者治疗无效,B组的疗效优于A组,差异有统计学意义(P<0.05);两组在给药过程中均发生轻微不良反应,停药后消失,不良反应发生率差异无统计学意义。结论左氧氟沙星联合头孢他啶用于预防晚期泌尿系肿瘤患者的感染,可以提高疗效,且未增加不良反应的发生,值得在临床工作中推广、应用。OBJECTIVE To explore the effect of levofloxacin combined with ceftazidime on treatment of infections in patients with advanced urinary tract tumors and summarize clinical experience so as to provide theoretical basis for treatment of the advanced urinary tract tumor patients with infections .METHODS A total of 120 patients with ad‐vanced urinary tract tumors who were treated in the hospital from Aug 2006 to Feb 2014 were randomly recruited as the study objects and divided into two groups ,with 60 cases in each ;the clinical data of the two groups of pa‐tients had significant difference and were comparable ;the group A was treated with levofloxacin ,while the group B was given the levofloxacin combined with ceftazidime ,with the treatment cycle of 14 days;the effect on treat‐ment of infections and the incidence of adverse reactions were observed and compared between the two groups . RESULTS Totally 22 （36 .7% ） cases were cured in the group A ,25 （41 .7% ） cases in the group B ;28 （46 .7% ） cases were effective in the group A ,32 （53 .3% ） cases in the group B ;7 （11 .7% ） cases were improved in the group A ,2 （3 .3% ） cases in the group B ;the total effective rate was 83 .3% in the group A ,95 .0% in the group B;3 cases were ineffective in the group A ,1 case in the group B ;the clinical efficacy of the group B was signifi‐cantly better than that of the group A （P〈0 .05） .The mild adverse reactions occurred in both groups during the drug therapy and disappeared after withdrawal of drugs ,and there was no significant difference in the incidence of adverse reactions .CONCLUSION Levofloxacin combined with ceftazidime can improve the clinical efficacy in treat‐ment of the infections in the patients with advanced urinary tract tumors ,without increasing of the incidence of ad‐verse reactions ,and it is worthy to be promoted in the hospital .

关 键 词：晚期泌尿系肿瘤 感染 左氧氟沙星 头孢他啶 联合用药 

分 类 号：R978[医药卫生—药品]