晚期小细胞肺癌患者时辰化疗期医院感染分析  

Nosocomial infections in advanced small cell lung cancer patients undergoing chrono-chemotherapy

作　　者：陈春荣 宋爱英 高玉艳[3] 赵德辉[1] 

机构地区：[1]齐齐哈尔医学院第一附属医院肿瘤内科,黑龙江齐齐哈尔161042 [2]黑龙江省中医药大学附属第一医院肿瘤内科,黑龙江哈尔滨150000 [3]哈尔滨医科大学附属肿瘤医院肿瘤内科,黑龙江哈尔滨150000

出　　处：《中华医院感染学杂志》2015年第5期1085-1087,共3页Chinese Journal of Nosocomiology

基　　金：黑龙江省科研攻关基金资助项目(GC07C35104);齐齐哈尔市科技基金资目项目(SFZD-2013124)

摘　　要：目的探讨时辰化疗对晚期小细胞肺癌患者的临床效果,以期增强临床诊治水平,延长患者生命。方法选取2010年5月-2013年8月130例晚期小细胞肺癌患者为研究对象,按住院号单双分为两组,每组各65例,对照组予常规西医治疗、观察组予时辰化疗,观察治疗后临床效果,并观察其感染发生率。结果临床效果比较,对照组总有效率、进展率分别为33.85%、44.61%,观察组患者分别为43.08%、27.69%;不良反应比较,对照组患者白细胞下降、贫血、血小板减少、恶心呕吐、脱发、肝肾毒性、水钠潴留及感染率分别为75.38%、47.69%、63.07%、69.03%、60.00%、44.61%、23.08%及33.85%,观察组患者分别为50.77%、30.77%、36.92%、47.7%、3.38%、30.77%、13.85%及21.54%,两组比较差异有统计学意义(P<0.05);另外两组在生活质量评分、疼痛评分、住院时间、平均生存时间、免疫功能指标比较差异均有统计学意义(P<0.05)。结论时辰化疗可提高晚期小细胞肺癌临床效果、降低感染率、提高生存质量。OBJECTIVE To explore the clinical effect of chrono‐chemotherapy on patients with advanced small cell lung cancer so as to intensify the level of clinical diagnosis and treatment and extend the lives of the patients . METHODS A total of 130 patients with advanced small cell lung cancer who were treated from May 2010 to Aug 2013 were enrolled in the study and divided into two groups according to odd and even number of hospitalization , with 65 cases in each ;the control group was treated with conventional western medicine ,while the observation group was given the chrono‐chemotherapy ;the clinical effect and the incidence of infections were observed after the treatment .RESULTS As compared with the clinical effects ,the total effective rate was 33 .85% in the control group ,43 .08% in the observation group ;the progress rate was 44 .61% in the control group ,27 .69% in the ob‐servation group .As compared with the adverse reactions ,the incidence of leucopenia was 75 .38% in the control group ,50 .77% in the observation group ;the incidence of anemia was 47 .69% in the control group ,30 .77% in the observation group ;the incidence of thrombocytopenia was 63 .07% in the control group ,36 .92% in the obser‐vation group ;the incidence of nausea and vomiting was 69 .03% in the control group ,47 .7% in the control group ;the incidence of alopecia was 60 .00% in the control group ,3 .38% in the observation group ;the incidence of liver and kidney toxicity was 44 .61% in the control group ,30 .77% in the observation group ;the incidence of water and sodium retention was 23 .08% in the control group ,13 .85% in the observation group ;the incidence of infec‐tions was 33 .85% in the control group ,21 .54% in the observation group ,there was significant difference be‐tween the two groups （P〈0 .05） .There was significant difference in the life quality score ,pain score ,length of hospital stay ,average survival time ,or immune function indicators between the two groups （P〈0 .05） .CONCLUSION The chrono‐

关 键 词：时辰化疗 晚期小细胞肺癌 临床效果 

分 类 号：R181.32[医药卫生—流行病学]