藏药密生波罗花中1个新的苯乙醇苷化学成分  

A new phenylethanoid glycoside from roots of Incarvillea compacta

作　　者：吴海峰[1] 黄园园[1,3] 张丽静[1] 张小坡[2] 马国需[1] 曹丽[1] 杨峻山[1] 许旭东[1] 

机构地区：[1]中国医学科学院北京协和医学院药用植物研究所,中草药物质基础与资源利用教育部重点实验室,北京100193 [2]海南医学院药学院,海南海口571101 [3]桂林医学院,广西桂林541004

出　　处：《中草药》2015年第4期476-480,共5页Chinese Traditional and Herbal Drugs

基　　金：“重大新药创制”科技重大专项“十二五”计划(综合性新药研究开发技术大平台)(2012ZX09301-002-001-026);药植所创新团队发展计划资助

摘　　要：目的研究藏药密生波罗花Incarvillea compacta根的化学成分。方法采用硅胶柱色谱、Sephadex LH-20、ODS柱色谱及高效液相制备色谱等方法进行分离纯化,根据理化性质及波谱数据确定化合物的结构。结果从密生波罗花根的95%乙醇提取物中分离得到4个苯乙醇苷类化合物,分别鉴定为Z-3′′′-异甲氧基圆齿列当苷（1）、3′′′-甲氧基圆齿列当苷（2）、圆齿列当苷（3）和异角胡麻苷（4）。结论化合物1为新化合物;化合物2~4为首次从角蒿属植物中分离得到。Objective To study the chemical constituents from the roots of Incarvillea compacta（Tibetan medicine）. Methods The constituents were isolated and purified by silica gel, Sephadex LH-20, ODS column chromatography, and preparative HPLC. Their structures were elucidated on the basis of their physicochemical properties and spectral data. Results Four phenylethanoid glycosides were obtained from the ethanol extract in the roots of I. compacta and identified as Z-3′′′-O-methylisocrenatoside（1）, 3′′′-O-methylcrenatoside（2）, crenatoside（3）, and isomartynoside（4）, respectively. Conclusion Compound 1 is a new phenylethanoid glycoside and compounds 2—4 are isolated from the plants of Incarvillea A. Juss. for the first time.

关 键 词：藏药 密生波罗花 苯乙醇苷 Z-3′′′-异甲氧基圆齿列当苷 圆齿列当苷 异角胡麻苷 

分 类 号：R284.1[医药卫生—中药学]