阳春砂杂交新种“春选1号”药理活性研究  

Study on pharmacological activity of new hybrids Amomum villosum(Spring No.1)

作　　者：张丹雁[1] 严娅娟[1] 鲁轮 赖小平[1] 

机构地区：[1]广州中医药大学中药学院,广东广州510006

出　　处：《中草药》2015年第4期554-557,共4页Chinese Traditional and Herbal Drugs

基　　金：国家科技部"十二五"国家科技支撑计划(2011BAI01B02)

摘　　要：目的探讨阳春砂杂交新种"春选1号"挥发油的药理活性,并与其母本"长果2号"进行比较。方法采用10%番泻叶致小鼠腹泻模型、二甲苯致小鼠耳廓肿胀模型、0.6%醋酸溶液致小鼠扭体模型,观察"春选1号"挥发油的止泻、抗炎、镇痛作用,以及对小鼠胃肠动力的影响;并与其母本阳春砂"长果2号"进行对比分析。结果 "春选1号"与"长果2号"的挥发油均具有显著的止泻作用,其效果与阳性药蒙脱石散相当;抗炎作用与醋酸地塞米松片差异不明显;镇痛效果均显著;对胃排空均有双向调节作用,高剂量对小肠推进有促进作用,低剂量无明显影响。结论阳春砂杂交新种"春选1号"与其母本"长果2号"挥发油药理活性无明显差异,可媲美传统品种阳春砂。Objective To explore the pharmacological activities of volatile oil in new hybrids of Amomum villosum（Spring No.1） and compare to the female parent ＂Longfruit No.2＂. Methods The auricle swelling model of mice was induced by xylene, the diarrhea model of mice was induced by 10% Senna, the writhing body model of mice was induced by 0.6% acetic acid solution to observe the pharmacological actions of volatile oil in ＂Spring No.1＂. Results The volatile oil in both ＂Spring No.1＂ and ＂Longfruit No.2＂ had significant antidiarrheal effect, their effect was equivalent to the positive drug（Montmorillonite Powder）. There was no significant difference in anti-inflammatory effect compared with the control group, the analgesic effect was significant. Both of them had the bidirectional regulation on gastric emptying. High dose of them had the stimulative effect in the small intestinal propulsion, and low dose of them had no significant effect. Conclusion There is no significant difference in pharmacological activity between the new hybrid species ＂Spring No.1＂ and its female parent. It could be comparable to the traditional cultivars of A. villosum. This study provides a scientific basis for expanding A. villosum medicinal resources.

关 键 词：阳春砂 春选1号 止泻 抗炎 镇痛 胃肠动力 

分 类 号：R285.5[医药卫生—中药学]