还阳参化学成分及生物活性研究  

Chemical constituents and bioactivity of Crepis tectorum linn.

作　　者：马淑丽[1] 李慧慧[1] 栗娜[1] 张文治[1] 

机构地区：[1]齐齐哈尔大学化学与化学工程学院,黑龙江齐齐哈尔161006

出　　处：《齐齐哈尔大学学报（自然科学版）》2015年第2期45-47,共3页Journal of Qiqihar University(Natural Science Edition)

基　　金：黑龙江省自然科学基金资助项目(B200907);黑龙江省博士后资助经费项目(LBH-Z10234);黑龙江省教育厅科学技术研究项目(11551532)

摘　　要：研究还阳参crepis tectorum linn.全草的化学成分。采用硅胶柱色谱、HPLC色谱等方法分离纯化,对还阳参浸膏进行化学成分的分离,根据理化性质和波谱数据进行结构鉴定。从还阳参提取物中分离得到了5个化合物,分别鉴定为:β-谷甾醇(β-sitosterol,1)、豆甾醇(stimastero,2)、羽扇豆酮(lupenone,3)、木栓酮(friedelin,4)、伪蒲公英甾醇乙酸酯(ω-taraxasteryl acetate,5)。化合物3为该植物中首次分离得到。正丁醇层提取物对玉米小斑病菌、玉米大斑病菌、草莓灰霉病菌有抑制作用。To study the chemical constituents isolated from crepis tectorum linn. Chemical constituents were isolated by column chromatography and semi-prepared HPLC, the structures were elucidated spectral data and physical-chemical properties, five compounds were isolated and respectively identified as fl-sitosterol（ 1 ）, stimastero （ 2 ）, lupenone （ 3 ）, friedelin （ 4 ）, to-taraxasteryl acetate 1 （ 5 ） . Compounds 3 is isolated from Crepis tectorum linn for the frist time. The acetone extract have inhibiting effect to Bipolaria maydis and Exserohilum turcicum and Botrytis cinerea pers

关 键 词：还阳参 化学成分 分离 生物活性 

分 类 号：R284.2[医药卫生—中药学]