镁合金支架材料AZ81表面PLGA(PTX)/PLLA/MAO涂层的研究  

PLGA(PTX)/PLLA/MAO Coating on the Surface of AZ81 Magnesium Alloy Stent Materials

作　　者：郭美卿[1] 黄棣[1] 戴震[1] 许鑫华[2] 陈维毅[1] 

机构地区：[1]太原理工大学,山西太原030024 [2]天津大学天津市复合材料与功能化重点实验室,天津300072

出　　处：《稀有金属材料与工程》2015年第2期412-418,共7页Rare Metal Materials and Engineering

基　　金：国家自然科学基金青年科学基金资助(51301117);山西省青年科技研究基金资助(2013021003-1;2013021014-2)

摘　　要：在AZ81镁合金表面制备了抗腐蚀和药物释放复合涂层,并对其耐蚀性、药物释放性能及生物相容性进行研究。DSC和红外光谱数据表明,紫杉醇均匀分散在PLGA体系中。药物释放数据表明30 d后,药物释放率在80%左右。SEM、电化学阻抗、极化及镁离子释放数据表明,PLLA涂层通过有效填充微弧氧化膜表面的微孔与裂缝提高了镁合金的耐腐蚀性。血液和细胞实验表明涂层镁合金血液相容性良好,无细胞毒性。A composite coating was prepared to control drug release and corrosion of magnesium alloys stent materials AZ81, and the corrosion resistance, drug release and biocompatibility were investigated. IR spectrum and DSC results show that paclitaxel can be evenly dispersed in the PLGA. The drug-release curves indicate that the cumulative release rate after 30 d reaches approximately 80%. SEM, the electrochemical impedance spectroscopy, polarization curve and magnesium release results suggest that the PLLA coating improve the corrosion resistance by preventing the corrosive ions from diffusing to the magnesium substrate. The blood and cell test results reveal that the samples have good hemocompatibility and no cytotoxicity.

关 键 词：镁合金 支架 紫杉醇 PLGA PLLA 

分 类 号：TG178[金属学及工艺—金属表面处理] R318.08[金属学及工艺—金属学]