我院门诊2013年7-12月超说明书用药及典型处方分析  

Analysis of Outpatient Typical Prescriptions of Off-label Drug Use in Our Hospital from Jul. to Dec. 2013

作　　者：王健[1] 陈燕华[1] 

机构地区：[1]南京大学医学院附属鼓楼医院药学部,南京210008

出　　处：《中国药房》2015年第8期1041-1043,共3页China Pharmacy

摘　　要：目的:为门诊合理用药提供参考。方法:利用华软门诊信息审方系统,从2013年7-12月660 708张处方中筛选出超说明书用药处方,查找现有期刊文献、处方集,对典型处方进行分析。结果:超说明书用药处方1 420张,占0.21%。其中,盐酸氟西汀胶囊用于早泄、勃起功能障碍,螺内酯片用于痤疮、脂溢性皮炎、雄激素源性脱发,胰激肽原酶肠溶片用于男性不育症,阿司匹林肠溶片、盐酸二甲双胍片、枸橼酸西地那非片用于不孕症,均属于超适应证用药。甲硝唑片阴道内给药属于超剂型用药。结论:我院门诊超说明书用药均有一定科学理论、临床试验证据的支持,但考虑其药品不良反应和使用风险,是否能推广使用仍需要更多临床研究。OBJECTIVE：To provide reference for the rational drug use in outpatient department. METHODS：Using SIOP software（Jssinosoft outpatient information system）,the prescriptions of off-label drug use were selected from 660 708 prescriptions during Jul. to Dec. 2013. The typical prescriptions were analyzed by searching the current periodicals and formulary. RESULTS：There were 1 420 prescriptions of off-label drug use,accounting for 0.21%. Fluoxertine hydrochloride capsule,Spironolactone tablet,Pancreatic kininogenase enteric-coated tablet,Aspirin enteric-coated tablet,Sildenafil citrate tablet and Metformin hydrochloride tablet were used beyond the indications. Metronidazole tablets with intravaginal administration belonged to drug use beyond dosage forms. CONCLUSIONS：Off-label drug use in outpatient department of our hospital all depended on scientific theories and clinical trials. Considering about ADR and the use of risk,whether it can be promoted still need more clinical research.

关 键 词：超说明书用药 处方分析 合理用药 

分 类 号：R95[医药卫生—药学] R969.3