右美托咪定在超声引导下经皮射频消融治疗肝肿瘤的临床应用  

Clinical Application of Ultrasound-guided Percutaneous Radiofrequency Ablation of Dexmedetomidine for Liver Tumors

作　　者：王新元[1] 甘建辉[1] 胡万宁[1] 高慧军[1] 柳浩然[1] 

机构地区：[1]河北联合大学附属唐山市人民医院,河北唐山063000

出　　处：《中国药房》2015年第8期1098-1100,共3页China Pharmacy

基　　金：河北省医学科学研究重点课题计划(No.20130674)

摘　　要：目的：探讨右美托咪定应用于超声引导下经皮射频消融治疗肝肿瘤的可行性。方法：将40例行超声引导下经皮射频消融治疗肝肿瘤的患者随机分成D组和L组,每组20例。D组患者于术前10 min持续输注右美托咪定0.5μg（/kg·h）,患者意识消失后开始手术;L组患者在术前10 min输注乳酸林格液的同时给予咪达唑仑0.05 mg/kg。两组患者均采用0.5%利多卡因局部麻醉,术中常规面罩给氧3~4 L/min。观察不同时点的心率（HR）、平均动脉压（MAP）、血氧饱和度（Sp O2）、镇静和疼痛评分。结果：两组患者给药前的HR、MAP、Sp O2差异无统计学意义（P〉0.05）,操作开始后L组出现心率和血压升高（P〈0.05）;D组的镇静评分和镇痛效果明显优于L组（P〈0.05）,Sp O2差异无统计学意义（P〉0.05）。结论：该研究中,右美托咪定用于超声引导下经皮射频消融治疗肝肿瘤是安全、有效的。OBJECTIVE：To investigate the feasibility of ultrasound-guided percutaneous radiofrequency ablation of dexmedetomidine for liver tumors. METHODS：40 patients scheduled ultrasound-guided percutaneous radiofrequency ablation of liver tumors were randomized into group D and group L with 20 cases in each group. Group D was continually given dexmedetomidine 0.5 μg（/kg·h）10 min before operation,and the operation was started after patients lost consciousness. Group L was given Lactated Ringer’s solution and midazolam 0.05 mg/kg 10 min before operation. Both group received local anaesthesia of 0.5% lidocaine,and mask oxygen inhalation 3-4 L/min during operation. The changes of HR,MAP,Sp O2,sedation and pain scores were recorded at different time points. RESULTS：Before medication,there was no statistically significant difference in HR,MAP and Sp O2 between 2 group（P〉0.05）. HR and MAP of group L were increased after starting operation（P〈0.05）. Sedation scores and analgesic effects of group D were better than that of group L（P〈0.05）. There was no statistically significant difference in Sp O2 between 2 groups（P〉0.05）. CONCLUSIONS：The ultrasound-guided percutaneous radiofrequency ablation of dexmedetomidine is safe and effective for liver tumors.

关 键 词：右美托咪定 超声 射频消融 肝肿瘤 镇静和疼痛评分 

分 类 号：R971.2[医药卫生—药品] R969.4[医药卫生—药学]