基于亚区结构的人体二尖瓣的建模与仿真  

Modeling and Simulation Methods for Mitral Valve Based on the Mitral Valve Sub-region

作　　者：赵晓佳[1] 宋晓[2] 黄晓阳[1] 苏茂龙[3] 钟琪[1] 

机构地区：[1]厦门大学信息科学与技术学院,福建厦门361005 [2]南阳师范学院计算机与信息技术学院,河南南阳473061 [3]厦门大学附属中山医院超声医学科,福建厦门361004

出　　处：《厦门大学学报（自然科学版）》2015年第2期276-280,共5页Journal of Xiamen University：Natural Science

基　　金：国家自然科学基金(61102137;61271336;61327001);福建省自然科学基金(2014J01438)

摘　　要：通过建立精细的人体二尖瓣有限元模型,仿真前后瓣叶厚度不均匀的二尖瓣模型在心脏收缩初期的动态闭合过程,与前后瓣叶厚度均匀的二尖瓣模型的仿真结果相比较.仿真结果表明:两种模型的瓣叶应力分布不均匀,最大应力值都出现在后瓣叶亚区与亚区之间的裂口位置,与临床二尖瓣撕裂常发生位置一致,表明了仿真方法以及结果的正确性,瓣叶厚度不均匀模型中瓣叶应力水平相对较低,更符合实际.最后根据临床数据,设置厚度不均匀模型中瓣环与乳头肌的二维运动,再次进行仿真.仿真结果表明该精细模型瓣叶的闭合度比之前瓣环与乳头肌固定不动模型的闭合度高,瓣叶应力分布相对较均匀,更接近实际生理情况,为后续的病理等的仿真奠定了基础.A fine model of the human mitral valve with non-uniform thickness has been established.The valve closure has been simulated using the finite element method during early systolic period,compared with the uniform one.Simulation results show that the stress is unevenly distributed on the leaflets,that the mitral valve with non-uniform has lower stress level than the uniform one.Furthermore,the maximum principal stresses occurs at the clefts between the three scallops in the posterior leaflet,indicating positions of the mitral valve cleft in clinic.The result is consistent with the physiology.It suggests that the method and the results are correct.Finally,based on clinical data,the motion of annulus and papillary muscles has been simulated,showing higher closure and relatively uniform stress distribution,closer to the actual physiological conditons.It laid the foundation for the simulation of subsequent pathology.

关 键 词：二尖瓣 有限元模型 应力分布 最大应力 

分 类 号：TP391[自动化与计算机技术—计算机应用技术]