罗红霉素联合氨溴索治疗稳定期支气管扩张症48例疗效观察  

Clinical Imaging Characteristics of Long-term Use of Antibiotics in Plateau Bronchiectasis Pa-tients

作　　者：陈洋[1] 李鑫[1] 王之赫 陆思静[1] 王玮[2] 

机构地区：[1]辽宁医学院附属第一医院呼吸内科,辽宁 锦州121001 [2]中国医科大学附属第一医院呼吸疾病研究所,辽宁 沈阳110001

出　　处：《医学临床研究》2015年第1期107-109,共3页Journal of Clinical Research

摘　　要：目的探讨罗红霉素联合盐酸氨溴索治疗稳定期支气管扩张症患者的疗效。方法96例稳定期支气管扩张症患者根据患者意愿分为观察组和对照组，每组48例，对照组患者采用盐酸氨溴索口服治疗，每次30mg，3次／日；观察组在对照组基础上服用罗红霉素，每次0．15g，1次／日。两组患者的疗程均为6个月。比较两组患者的生活质量评分、呼吸困难评分和胸部CT影像学评分。结果治疗后，观察组患者生活质量评分、呼吸困难评分及除病变肺叶评分的其他胸部CT影像学评分指标均低于对照组，差异均具有显著性（ P ＜0．05）。结论罗红霉素联合盐酸氨溴索治疗稳定期支气管扩张症患者，能显著降低患者的生活质量评分、呼吸困难评分和胸部CT影像学总评分，疗效满意，值得临床推广应用。[Objective]To explore the effects of long‐term antibiotics on stable bronchiectasis patients .[Methods]A total of 96 bronchiectasis patients in stable stage were divided into observation and control groups （ n =48 each） .The control group received oral ambroxol hydrochloride 30 mg ,thrice daily while the observa‐tion group took roxithromycin 0 .15 g ,once daily plus oral ambroxol hydrochloride 30 mg ,thrice daily .After 6‐month treatment ,two groups were compared with regards to the scores of quality of life ,dyspnea and chest computed tomography （CT） imaging .[Results]After treatment ,the observation group had lower scores than those of control group .And the differences were significant （ P〈0 .05） .[Conclusion]In the treatment of sta‐ble bronchiectasis ,a combination of roxithromycin and ambroxol hydrochloride can significantly reduce the to‐tal scores of quality of life score ,dyspnea and chest CT imaging .Such a regimen is worthy of wider applica‐tions .

关 键 词：罗红霉素/治疗应用 氨溴索/治疗应用 支气管扩张症/药物疗法 治疗结果 

分 类 号：R562.22[医药卫生—呼吸系统]