前列地尔联合阿卡波糖治疗2型糖尿病肾病的疗效及对氧化应激水平的影响  

Curative Efficacy of Prostaglandine1 Plus Acarbose and its Effects on Oxidative Stress in Pa-tients with Type 2 Diabetic Nephropathy

作　　者：戴爱明 李翠兰[2] 

机构地区：[1]湖南省邵阳市中心医院,湖南 邵阳422001 [2]湖南省邵阳市第一人民医院,湖南 邵阳422001

出　　处：《医学临床研究》2015年第1期113-115,共3页Journal of Clinical Research

摘　　要：目的探讨前列地尔联合阿卡波糖治疗2型糖尿病肾病的疗效及对患者氧化应激水平的影响。方法将本院收治的85例2型糖尿病肾病患者按治疗方案不同分为对照组（40例）和观察组（45例）。对照组在常规治疗的基础上给予阿卡波糖100 m g ，3次／日，观察组在对照组的基础上联合应用前列地尔10μg ，1次／日进行治疗。4周后观察比较两组患者临床疗效、肾功能、丙二醛（MDA），超氧化物歧化酶（SOD）水平变化及不良反应发生情况。结果观察组的总治疗有效率为88．9％，明显高于对照组的77．5％，且两组相比较差异有显著性（Z＝2．15，P＜0．05）。经治疗后观察组肾功能指标血尿素氮（BUN）和血肌酐（SCr）、尿总蛋白明显下降，SOD明显升高，MDA明显下降，与对照组相比差异均有显著性（ P ＜0．05）。治疗过程中两组患者均无明显严重不良反应发生。结论前列地尔联合阿卡波糖可以显著提高2型糖尿病肾病的治疗有效率，改善肾功能，减轻氧化应激水平，且不良反应轻微，值得临床上推广应用。[Objective]To explore the clinical efficacy of prostaglandin e1 plus acarbose and its effects on oxidative stress in patients with type 2 diabetic nephropathy （DN） .[Methods]A total of 85 cases of type 2 DN fulfilling the inclusion criteria were divided into two groups according to therapeutic protocol .Besides conven‐tional treatments ,the control group treated acarbose 100 mg ,thrice daily while the observation group took prostaglandin e1 10 μg ,once daily and acarbose 100 mg thrice daily .Then their curative efficacy ,renal func‐tion ,oxidative stress and adverse reactions were observed and compared .[Results]The observation group had a therapeutic efficiency ratio （TER） of 88 .9% and it was significantly higher than that of 77 .5% in control group （Z=2 .15 ,P〈0 .05） .In comparison with control group after treatment ,the renal function indices of blood urea nitrogen ,serum creatinine and urine total protein were statistically lower in observation group （ P〈0 .05） .As to oxidative stress ,compared to control group ,malondialdehyde were statistically lower while superoxide dismutase was statistically higher in observation group （ P 〈0 .05） .During treatment ,there was on onset of severe adverse reactions .[Conclusion]Combined treatment of prostaglandin e1 and acarbose is effi‐cacious for type 2 DN .It can significantly increase therapeutic efficiency ratio ,improve renal function and alle‐viate oxidative stress with minor adverse reactions .

关 键 词：前列地尔/治疗应用 阿卡波糖/治疗应用 糖尿病肾病/药物疗法 糖尿病 2型/并发症 氧化性应激 

分 类 号：R587.24[医药卫生—内分泌]