巨噬细胞移动抑制因子及相关因子在宫颈鳞癌组织中的表达及意义  

Expression of Macrophage Migration Inhibition Factor and Related Factors in Cervical Squamous Carcino-ma and Its Significance

作　　者：尹巧燕 步兰娜 

机构地区：[1]河北省邯郸市妇幼保健院,河北 邯郸056002

出　　处：《医学临床研究》2015年第1期116-118,121,共4页Journal of Clinical Research

摘　　要：目的探讨宫颈鳞癌（SCC）中巨噬细胞移动抑制因子（MIF）、金属蛋白酶‐9（MMP‐9）和血管内皮生长因子（VEGF）的表达及意义。方法选择SCC组织标本51份（SCC组）、宫颈上皮内瘤样病变（CIN）标本41份（CIN组），正常宫颈组织（NCE）标本32份（NCE组），采用免疫组化SP法检测各组MIF 、MMP‐9和VEGF的表达并比较分析。结果 NCE组、CIN组、SCC组MIF、MMP‐9、VEGF阳性率及微血管密度（MVD）值依次升高，组间比较有统计学差异（ P ＜0．05），且SCC组显著高于CIN组、NCE组；MIF、MMP‐9和VEGF在SCC组织中的阳性表达均与组织分化程度、有无淋巴结转移、临床分期有关（ P ＜0．05）；MIF、MMP‐9和VEGF阳性表达的M VD值与SCC临床分期、分化程度、淋巴结转移显著相关（ P ＜0．05）；在SCC中M IF和M M P‐9的表达呈显著正相关（ P ＜0．05），而VEGF和MIF、MMP‐9的表达无相关性（ P ＞0．05）。结论 MIF、MMP‐9和 VEGF在SCC的发生、发展、浸润及转移中起重要作用；SCC组织学分化越差，MIF、MMP‐9和VEGF阳性表达率及MVD值越高，提示三者联合检测可为评估SCC严重程度。[Objective] To explore the expression of macrophage migration inhibition factor（MIF） ,metalloprotease‐9 （MMP‐9） and vascular endothelial growth factor（VEGF） in squamous carcinoma of the cervix（SCC） .[Methods]A total of 51 SCC samples（SCC group） ,41 cervical intraepithelial neoplasia（CIN） samples（CIN group） and 32 normal cervix （NCE） sample（NCE group） were chosen .The expressions of MIF ,MMP‐9 and VEGF were detected by immunohisto‐chemical SP method ,and compared and analyzed .[Results] The positive rates of MIF ,MMP‐9 and VEGF and MVD value in NCE ,CIN and SCC groups were increased by turns ,and there was significant difference（ P〈0 .05） ,and those in SCC group were markedly higher than those in CIN and NCE groups .The positive expression rates of MIF ,MMP‐9 and VEGF in SCC group were correlated with histological differentiation ,lymph node metastasis and clinical stage（ P〈0 .05） .The positive expression rates of MIF ,MMP‐9 and VEGF and MVD value were markedly correlated with clinical stage ,differentiation and lymph node metastasis of SCC（ P〈0 .05） .The expression of MIF in SCC was markedly corre‐lated with the expression of MMP‐9（ P〈0 .05） ,but the expression of VEGF was not correlated with the expressions of MIF and MMP‐9（ P〉0 .05） .[Conclusion]MIF ,MMP‐9 and VEGF may play an important role in the occurrence ,de‐velopment ,infiltration and metastasis of SCC .The poorer the histological differentiation of SCC is ,the higher the expres‐sions of MIP ,MMP‐9 and VEGF and MVD value are .It indicates that the combination detection can evaluate the severity of SCC .

关 键 词：癌 鳞状细胞 宫颈肿瘤 宫颈上皮内瘤样病变 巨噬细胞游走抑制因子/生物合成 基质金属蛋白酶9/代谢 血管内皮生长因子A/代谢 

分 类 号：R711.74[医药卫生—妇产科学]