何首乌中大黄素的研究进展  

Advance of Studies on Emodin in Polygonum Multiflorum

作　　者：左启敏 冯艳果[1,2] 吴婷婷[1,2] 曹树强[1,2] 杨玉娟[1,2] 汪选斌[1,2] 李洪亮[1,2] 刘英[1,2] 

机构地区：[1]湖北医药学院附属人民医院中药药理实验室/武当特色中药研究湖北省重点实验室,湖北十堰442000 [2]湖北医药学院药学院,湖北十堰442000

出　　处：《山东化工》2015年第5期54-58,共5页Shandong Chemical Industry

基　　金：湖北医药学院2013年大学生创新创业训练计划国家级项目(201310929008);湖北省2011计划项目(项目编号:4);湖北省自然基金面上项目(2014CFB642);湖北省十堰市2011年民生科技专项(2011057);湖北医药学院优秀中青年团队项目(2014CXG03);湖北医药学院教学研究立项项目(2013029)

摘　　要：总结何首乌中大黄素的提取工艺、定量分析、药理活性及毒性的研究现状,为何首乌中大黄素的进一步研究提供文献依据和研究思路。以何首乌、大黄素为检索词,检索2000年以来Pub Med、CNKI、万方、重庆维普数据库,对相关文献进行总结、分析。何首乌中的大黄素具有治疗癌症、骨质疏松、炎症、便秘、肝保护、心肌保护、抗衰老等作用,但亦有泻下、肝损伤、胃肠道反应、促进神经兴奋等不良反应。何首乌中的大黄素具有一定的潜在的药用价值,其与何首乌中其它成分之间的相互作用值得深入研究。To summarize the studies on emodin in Polygonum Multiflorum Thunb, including extraction process, quantitative analysis, pharmacological actions and toxicity, which may provide literature basis for further studies. The key words of ＂Polygonum Multiform＂ and ＂emodin＂ in PubMed, CNKI, WanFang and VIP databases were retrieved from 2000 to present with summarizing and analyzing. The emodin in Polygonum Multiflorum can be used for treating cancer, osteoporosis,inflammation,coprostasis , liver and myocardial protection and anti - aging. While it could lead to adverse drug reactions such as diarrhea, liver damage, digestive system and central nerve system disorders. The emodin in Polygonum Multiflorum has great potential for medicinal use. Its interactions with other components in Polygonum Multiflorum should be worth of further study.

关 键 词：何首乌 大黄素 定量分析 药理活性 毒性 

分 类 号：R284.2[医药卫生—中药学]