pH敏感型交联微球的制备  

Preparation and Characterization of pH Sensitive Crosslinked Microspheres

作　　者：张建平[1] 郭建峰[1] 张尧[1] 杨姣[1] 

机构地区：[1]中北大学化工与环境学院,山西太原030051

出　　处：《石油化工》2015年第3期370-374,共5页Petrochemical Technology

基　　金：山西省科技攻关项目(20130321017-03);海南省重点科技计划项目(ZDXM20130089)

摘　　要：采用铈盐-羟基氧化还原引发体系,以对苯乙烯磺酸钠(SSS)和葡聚糖(Dex)为原料,通过自由基接枝聚合将聚对苯乙烯磺酸钠(PSSS)接枝到Dex上,得到接枝共聚物Dex-g-PSSS,再通过交联反应合成C(Dex-g-PSSS)微球。利用FTIR、光学显微镜、Zeta电位仪表征了试样的结构和形态,研究了反应条件对PSSS接枝度的影响,考察了C(Dex-g-PSSS)微球在模拟胃液和结肠液中的溶胀率。表征结果显示,C(Dex-g-PSSS)微球为交联微球,其Zeta电位为绝对值较大的负值。实验结果表明,在适宜的反应条件(硫酸铈铵浓度12 mmol/L、H+浓度0.08 mol/L、Dex 5 g、SSS 5 g、50℃,6 h)下,可得到接枝度为11.86 g(基于100 g Dex-g-PSSS)的PSSS。C(Dex-g-PSSS)微球有较明显的p H敏感性,它在模拟胃液中的溶胀率仅有134%,在模拟结肠液中的溶胀率可达到678%,是潜在的口服结肠定位给药系统基质材料。A graft copolymer,Dex-g-PSSS,was synthesized through free radical graft copolymerization of sodium 4-styrene sulfonate（SSS） and dextran（Dex） with cerium salt-hydroxyl group redox initiation system. And then C（Dex-g-PSSS） microspheres were prepared by crosslinking reaction. Dex,Dex-g-PSSS and C（Dex-g-PSSS） were characterized by means of FTIR,optical microscope and Zeta potential analyzer. The swelling ratios of C（Dex-g-PSSS） in the simulated gastric and intestinal juices were studied. The results showed the crosslinked microsphere structure and negative Zeta potential of C（Dex-g-PSSS）. Under the optimum conditions of c（ammonium cerous sulfate） 0.012 mol/L,c（H＋） 0.08 mol/L,Dex 5 g,SSS 5 g,50 ℃ and 6 h,the grafting degree of PSSS was 11.86 g（based on 100 g Dex-g-PSSS）. C（Dex-g-PSSS） possesses obvious p H sensitivity and its swelling ratios in the simulated gastric and intestinal juices reached 134% and 678%,respectively. The C（Dex-g-PSSS） microspheres are a potential material for oral colon-specific drug delivery system.

关 键 词：PH敏感 交联微球 葡聚糖 对苯乙烯磺酸钠 口服结肠定位给药系统 接枝聚合 

分 类 号：TQ316.343[化学工程—高聚物工业]