肺炎支原体肺炎发病机制及相关临床问题  

Research progress of the pathogenesis of mycoplasma pneumoniae pneumonia and its related clinical problems

作　　者：王菲[1] 尚云晓[1] 

机构地区：[1]中国医科大学附属盛京医院小儿呼吸内科,辽宁沈阳110004

出　　处：《中国实用儿科杂志》2015年第3期184-189,共6页Chinese Journal of Practical Pediatrics

摘　　要：肺炎支原体(MP)是社区获得性肺炎的常见病原,致病机制主要包括对气道上皮的细胞黏附作用,产生氧化应激;释放CARDS TX,导致细胞代谢异常;引起免疫反应,导致免疫损伤;侵入白细胞内直接致病。难治性MP肺炎通常指正规应用大环内酯类抗生素临床症状未见明显好转的MP肺炎;C-反应蛋白(CRP)明显升高、肺部大面积实变及呼吸道纤毛超微结构异常等可能提示RMPP。通常应用大环内酯类抗生素及四环素、喹诺酮类、氨基糖苷类抗生素通过干扰和抑制蛋白质合成而治疗MP感染。RMPP患儿行支气管镜治疗对改善预后有积极作用。Mycoplasma pneumoniae（MP） is a common cause of community-acquired pneumonias. The airway epithelialcell adhesion effect of MP can lead to oxidative stress; CARDS TX is released disturbing the cell metabolism; MP alsocauses direct pathogenic immune response, leading to immune damage and invades into the white blood cells causing la-tent or chronic infections. RMPP usually refers to mycoplasma pneumonia deterioration despite the appropriate macro-lides treatment.Arised CRP, large area consolidation of lung and ciliary ultrastructural abnormalities may prompt RMPP.Macrolide antibiotics tetracyclines, quinolones and aminoglycosides are used in Mycoplasma pneumoniae infection by in-hibiting and interfering the protein synthesis. Bronchoscopic treatment of RMPP has a positive effect in improving theprognosis.

关 键 词：肺炎支原体 支气管镜 难治性肺炎支原体肺炎 

分 类 号：R72[医药卫生—儿科]