实验室检测指标和孕妇信息对重度子痫前期的预测  

Laboratory detection indicators and pregnant information for predicting severe preeclampsia in pregnant women

作　　者：李维[1] 张伟[1] 郑伟琳 刘梦莹[1] 李文雅[1] 张静[1] 

机构地区：[1]深圳市南山区妇幼保健院检验科,广东深圳518052 [2]深圳市南山区妇幼保健院产科,广东深圳518052

出　　处：《国际检验医学杂志》2015年第5期591-593,共3页International Journal of Laboratory Medicine

基　　金：深圳市科技局基金资助项目(201202175)

摘　　要：目的用实验室检测指标、孕妇信息预测重度子痫前期。方法收集重度子痫前期80例,对照444例。将疾病组和对照组的实验室检测指标、孕妇信息进行比较。用logistic回归和ROC曲线分析各指标对重度子痫前期的预测价值。结果早期体质量指数(BMI)、平均动脉压(MAP)、红细胞压积(HCT)、血小板(PLT)、中期BMI、MAP与重度子痫前期呈正相关,早期人绒毛膜促性腺激素(HCG)和妊娠相关蛋白A(PAPP-A)呈重度子痫前期负相关。对重度子痫前期预测价值大的单个指标包括早期PAPP-A、早期和中期MAP。预测价值最大的联合指标是早中期MAP联合。结论早期PAPP-A、早中期MAP均能预测随后发生的重度子痫前期。Objective To use the laboratory detection indicators and pregnant information to predict severe preeclampsia in pregnant women.Methods 80 pregnant women with severe preeclampsia were collected as the disease group,and 444 cases were selected as the control group.Their laboratory detection indicators and pregnant information were compared.between the two groups.The Logistic regression and the ROC curve were used to analyze the predictive value of each indicator for predicting severe preeclampsia.Results BMI,MAP,HCT,PLT in the first trimester of pregnancy and BMI,MAP in the second trimester of pregnancy were positively correlated with severe preeclampsia.HCG and PAPP-A in the first trimester of pregnancy were negatively correlated with severe preeclampsia.The single indicators with large predicting value for severe preeclampsia included PAPP-A in the first trimester and MAP in the first and second trimesters of pregnancy.The combining MAP in the first and second trimester of pregnancy had the largest predictive value.Conclusion PAPP-A in the first trimester and MAP in the first and second trimester of pregnancy can predict subsequent severe preeclampsia.

关 键 词：子痫前期 实验室检查 孕检 预测价值 

分 类 号：R714.244[医药卫生—妇产科学] R446.1[医药卫生—临床医学]