儿童尿路感染细菌耐药情况及临床特征  

Bacterial drug resistance situation and clinical features of urinary tract infection in children

作　　者：余建华[1] 张书婉 贾凯[1] 杨维娜[1] 王璐[1] 王娟[1] 蔡慧君[1] 刘家华[1] 曹三成[1] 

机构地区：[1]西安市儿童医院检验科,陕西西安710003

出　　处：《国际检验医学杂志》2015年第5期633-635,共3页International Journal of Laboratory Medicine

摘　　要：目的分析儿童尿路感染（UTI）患者基本临床特征、辅助诊断指标、细菌感染谱及耐药情况,旨在为儿童UTI的预防、诊断、治疗提供依据。方法收集2012年1月至2014年3月在西安市儿童医院诊断为UTI或合并UTI的住院患者临床资料,剔除重复菌株,综合分析复杂性UTI患者与非复杂性UTI患者致病菌的差异。结果儿童首次UTI发病高峰在0～0.5岁。大肠埃希菌、克雷伯菌属以及铜绿假单胞菌是儿童UTI的主要致病菌,其中大肠埃希菌110株,占52.9%。UTI肠杆菌科致病菌对碳青霉烯类抗菌药物有较高的敏感度,耐药率小于10%;其他所检测的抗菌药物耐药率均大于20%。结论该地区住院患儿UTI耐药率较高,在治疗儿童UTI时,应结合当地细菌耐药的情况及疾病的严重程度合理使用抗菌药物,避免细菌耐药加剧。Objective To analyze the basic clinical characteristics,auxiliary diagnostic indexes,bacterial infection spectrum and drug resistance of child urinary tract infection to provide the basis for the prevention,diagnosis and treatment of child UTI.Methods The clinical data in the inpatients with UTI or complicating UTI in our hospital from January 2012 to March 2014 were collected.The repeated strains were excluded.The differences in the pathogens between the patients with complicated UTI and the patients with non-complicated UTI were comprehensively analyzed.Results The onset peak of child UTI for the first time was 0-0.5years old.Escherichia coli,Klebsiellaand Pseudomonas aeruginosa are the major pathogens of child UTI,in which 110 strains were Escherichia coli,accounting for 52.9%.The enterobacteriaceae pathogens of UTI had higher sensitivity to carbapenems antibacterial drugs,with the resistance rate of less than 10%;the resistance rate of others detected antibacterial drugs was more than 20%.Conclusion UTI in the children inpatients of this area has higher drug resistance rate,in the treatment of child UTI,the antibacterial drugs should be rationally used by combining the bacterial drug resistance situation in the local place and the disease severity in order to avoid the aggravation of bacterial drug resistance.

关 键 词：尿路感染 病原菌 耐药性 儿童 

分 类 号：R446.5[医药卫生—诊断学] R726.9[医药卫生—临床医学]