浅析“有故无殒,亦无殒”思想的科学内涵  

Analysis of the scientifi c connotation of ‘Medicine leads to no damage, also needs no excess in sick condition' Thought

作　　者：马骁[1] 何璇[2] 刘甜甜[1] 陈哲[1] 王建[1] 

机构地区：[1]成都中医药大学药学院,四川成都611137 [2]四川大学生物治疗国家重点实验室,四川成都610041

出　　处：《中药与临床》2014年第6期40-42,共3页Pharmacy and Clinics of Chinese Materia Medica

摘　　要："有故无殒,亦无殒"原指妊娠妇女在"大积大聚"状态下,可以适度合理使用大热大寒或峻猛药物达到治疗效果,同时也不会对孕妇及胎儿造成影响;但应中病即止,切勿因过度用药伤及孕妇及胎儿。现今其科学内涵已引申到生理病理用药差别的各个方面,不同的机体状态下,药物的作用不同,造成生理病理状态下药物反应不一致的原因,与药效差异、机体耐受性以及药代动力学特征有密切关系。因此,在临床用药时,应当重视不同机体状态,辨证施治,合理适当地使用药物,以期达到既能保证药物的安全性,又能有效地治疗疾病的目的。‘Medicine leads to no damage, also needs no excess in sick condition＇ originally refers to gravidas, in severe concretions and gatherings, can be reasonably and moderately treated with excessive hot or cold, fi erce medicine. In the meantime, it will cause no harm to pregnant women and fetus before disease is cured. Nowadays, the scientifi c connotation has been extended to the distinction of medication in physiology and pathology condition. Different organism status leads to disparate drug effect. The reasons are relevant to different effi cacy, body tolerance and pharmacokinetic characteristics. Therefore, in order to medicate effectively and safely, attention should be focalized on different status and pattern identifi cation based on determining treatment in clinical medication.

关 键 词：有故无殒 药效差异 机体耐受性 药代动力学特征 中药理论 

分 类 号：R285.5[医药卫生—中药学]