GLP-1及其类似物的胰外作用研究进展  

Progress of Extrapancreatic Effects by GLP-1and Its Analogues

作　　者：赵丽娟[1] 蒋琳[1] 

机构地区：[1]南京医科大学第一附属医院内分泌科,江苏南京210029

出　　处：《医学与哲学（B）》2015年第1期68-70,94,共4页Medicine & Philosophy(B)

摘　　要：近年来越来越多的研究表明,胰高血糖素样肽1(GLP-1)及其类似物除作用于胰腺β细胞和α细胞从而达到血糖控制以外,尚存在多种生物学效应,从而发挥许多重要的胰腺外作用,包括对心血管系统的保护、降低体重、调节脂代谢、改善胰岛素敏感性,以及对于肾脏、肝脏、肺脏、生殖内分泌等各脏器系统的功能调节作用,甚至具有潜在的抗肿瘤效应,未来可能在多个疾病领域广泛使用。In recent years, more and more studies showed that GLP-1 and its analogues still have a variety oi biologtcal effects besides their role of glycemic control. In addition to pancreatic beta cells and alpha ceils, they also play many important roles outside the pancreas including the protection of cardiovascular system, reduction of weight, improvement of insulin sensitivity, regulation of lipid metabolism and so on. Effects on renal, liver and the reproductive endocrine system have been reported. To our surprise, GLP-1 and its analogues even have potentially antineoplastic effect. In view of this, GLP-1 and its analogues may be widely used in multiple therapeutic areas in the future.

关 键 词：胰高血糖素样肽1 胰腺外作用 心血管 

分 类 号：R587.1[医药卫生—内分泌]