泽漆乙酸乙酯萃取物对小鼠经口急性毒性  

Acute Oral Toxicity of Euphorbia helioscopia'Ethylacetate Extract in Mice

作　　者：孙雪[1] 李明会[2] 张庆[2] 粟杨静[2] 

机构地区：[1]西南林业大学,昆明650224 [2]云南省森林灾害预警与控制重点实验室(西南林业大学)

出　　处：《东北林业大学学报》2015年第3期109-111,共3页Journal of Northeast Forestry University

基　　金：云南省森林灾害预警与控制重点实验室科研开放基金资助(ZK09A314);西南林业大学动物学重点学科建设项目资助(XKX200903)

摘　　要：研究了泽漆(Euphorbia helioscopia)乙酸乙酯萃取物的灭鼠毒性,评价了其灌胃GHS毒性类别,并以点斜法测定其灌胃LD50和LD10。结果表明:泽漆乙酸乙酯萃取物属于GHS 3类,有较好的杀鼠活性,其灌胃LD50为314.80 mg·kg-1,95%置信区间是(314.80±38.29)mg·kg-1,最低致死剂量估计值LD10为220.53 mg·kg-1,LD10的95%置信区间是(220.53±35.61)mg·kg-1。萃取物对灌胃的KM小鼠造成了多项生理指标的显著变化,对KM小鼠心脏、肝脏、脾脏、肺脏、肾脏均造成了不同程度的损伤,并表现出多种明显的中毒症状。With Kunming mouse as test animal,we studied Euphorbia helioscopia＇s toxicity and appraised the GHS class of E.helioscopia＇s extract by one-time intragastric administration.The intragastric administration＇s LD50 of Euphorbia helioscopia＇s ethylacetate extract.Ethylacetate extract of Euphorbia helioscopia was GHS Lever 3,and had good mouse killing active.All extracts effected moise＇s physical signs,and created obviously different poison symptoms.The intragastric administration＇s LD50 of Euphorbia helioscopia＇s ethylacetate extract was 314.80 mg·kg-1.The 95% confidence interval was（314.80±38.29） mg·kg-1.The lowest killed does estimated value was LD10 of 220.53 mg·kg-1,and at 95% confidence interval it was（220.53±35.61） mg·kg-1.Ethylacetate extract made significant changes on many physiological indexes of mouse,and injured heart,liver,spleen,lung,kidney in varying degrees.

关 键 词：泽漆 乙酸乙酯萃取物 灭鼠毒性 中毒表现 脏器质量 

分 类 号：R285.5[医药卫生—中药学]