基于中医药古籍的何首乌安全性及风险因素分析  

Safety and risk factor analysis on Polygoni Multiflori Radix base on ancient traditional Chinese medicine literatures

作　　者：宋海波[1] 杜晓曦[1] 郭晓昕[1] 任经天[1] 杨乐[1] 逄瑜[1] 

机构地区：[1]国家食品药品监督管理总局药品评价中心,北京100045

出　　处：《中国中药杂志》2015年第5期985-988,共4页China Journal of Chinese Materia Medica

基　　金：国家"重大新药创制"科技重大专项(2011ZX090304-08)

摘　　要：中药何首乌Polygoni Multiflori Radix为蓼科植物何首乌Polygortum multiflorum Thunb.的干燥块根,临床应用记载首见于唐代,历代本草文献对何首乌的基原、功效、毒性、炮制、使用禁忌等多有论述。近年来,随着公众健康意识的增强,何首乌及其成方制剂在治疗和预防疾病中的使用更为广泛,涉及何首乌肝损伤的文献报道也逐渐增加,何首乌的安全性问题日益引起社会的关注。该文对历代本草中记载的何首乌毒性及用药风险因素进行了归纳分析,提出在安全性研究中应重点关注种植、炮制方法等对何首乌的成分和毒性的影响,为进一步的研究提供了线索。Traditional Chinese medicine Polygoni Multiflori Radix is dried roots of Polygonaceae Polygortum multiflorum Thunb. Its clinical application records were first discovered in literatures of the Tang dynasty. The origins, efficacy, toxicity, processing and ta- boos of Polygoni Muhittori Radix have been discussed in many ancient herb literatures. In recent years, with the increase in the public awareness in health, Polygoni Multiflori Radix admits preparations have been more widely applied in the treatment and prevention of diseases. However, there have been more and more reports about Polygoni Multiflori Radix induced liver injury, the safety of Polygoni Multiflori Radix has increasingly attracted attention of the society. In this paper, the authors summarized and analyzed the toxicity and medication risk factors of Polygoni Multiflori Radix recorded in ancient herb literatures, and proposed that more attention shall be given to the effect of the planting and processing methods on the components and toxicity of Polygoni Multiflori Radix in safety studies, which provides clues for the further studies.

关 键 词：何首乌 安全性 文献研究 

分 类 号：R282.7[医药卫生—中药学]