右旋糖酐铁与蔗糖铁治疗胃大部切除术后缺铁性贫血的疗效及安全性比较  

Comparison on the Efficacy and Safety of Iron Dextran and Iron Sucrose for Treatment of Iron Deficiency Anemia after Subtotal Gastrectomy

作　　者：张均钧 华燕艳[2] 

机构地区：[1]余姚市第四人民医院普外科,浙江余姚315470 [2]无锡市第四人民医院肿瘤介入科,江苏无锡214000

出　　处：《中国药房》2015年第9期1205-1207,共3页China Pharmacy

摘　　要：目的:比较右旋糖酐铁与蔗糖铁治疗胃大部切除术后缺铁性贫血的临床疗效及安全性。方法:将90例胃大部切除术后缺铁性贫血患者随机均分为右旋糖酐铁组和蔗糖铁组。所有患者均于胃大部切除术后给予抗溃疡、胃肠减压、抗感染等常规治疗。在此基础上,右旋糖酐铁组患者给予右旋糖酐铁注射液100 mg,深部肌肉注射,每周3次;蔗糖铁注射液组患者给予蔗糖铁注射液100 mg加入0.9%氯化钠注射液10 ml中,静脉滴注,每周3次。两组患者疗程均为2周。观察两组患者的临床疗效,治疗前后血常规指标[血红蛋白(HGB)、血细胞比容(HCT)、平均红细胞血红蛋白浓度(MCH)、血清铁蛋白(SF)、转铁蛋白饱和度(TS)]、术后恢复情况(感染例数、平均住院天数)及不良反应发生情况。结果:两组患者的总有效率、术后恢复情况比较,差异均无统计学意义(P>0.05)。治疗前两组血常规指标比较,差异均无统计学意义(P>0.05);治疗后两组患者血常规指标均显著高于同组治疗前,差异有统计学意义(P<0.05),但两组间比较差异无统计学意义(P>0.05)。蔗糖铁组患者不良反应发生率显著低于右旋糖酐铁组,两组比较差异有统计学意义(P<0.05)。结论:右旋糖酐铁、蔗糖铁治疗胃大部切除术后缺铁性贫血的疗效相当,但蔗糖铁的安全性优于右旋糖酐铁。OBJECTIVE： To compare the efficacy and safety between iron dextran and iron sucrose treatment on iron deficien- cy anemia after subtotal gastrectomy. METHODS ： A total of 90 patients with iron deficiency anemia after subtotal gastrectomy were randomly divided into iron dextran group and iron sucrose group. They were all given subtotal gastrectomy. After operation, conven- tional treatment was conducted, including anti-ulcer, decompression, and anti-infection, etc. Based on it, the dextriferron group was given iron dextran injection 100 mg with deep intramusalar injection, 3 times a week; the iron sucrose group was given iron sucrose injection 100 mg added into 0.9% sodium chloride injection 100 ml with intravenous infusion, 3 times a week. The course was 2 weeks. The clinic data was observed, including efficacy, the blood routine index [hemoglobin （HGB）, hematocrit （HCT）, mean corpuscular hemoglobin concentration （MCH）, serum ferritin （SF） and transferrin saturation （TS）] before and after treat- ment, postoperative recovery （infected cases and average hospital stay） and adverse reactions （ADR）. RESULTS： There were no significant differences in the total efficacy and postoperative recovery（P〉0.05）. And there were no significant differences in the blood routine indexes before treatment （P〉0.05）. After treatment, the blood routine indexes were significantly higher than before, with significant difference（P〈0.05）, but there was no significant difference between 2 groups（P〉0.05）. The incidence of ADR in iron sucrose group was significantly lower than iron dextran group, with significant difference （P〈0.05）. CONCLUSIONS： Iron dextran and iron sucrose have equivalent efficacy in the treatment of iron deficiency anemia after subtotal gastrectomy, but iron sucrose has better safety.

关 键 词：右旋糖酐铁 蔗糖铁 胃溃疡穿孔 胃大部切除术 贫血 

分 类 号：R453.9[医药卫生—治疗学]