阿奇霉素治疗支原体肺炎患儿的临床观察  

Clinical Observation of Azithromycin in Treatment of Children with Mycoplasma Pneumonia

作　　者：郭惠娟[1] 江美芳[2] 洪先欧[3] 钟明[1] 李小群[1] 王丰[1] 

机构地区：[1]深圳市宝安区妇幼保健院药剂科,广东深圳518133 [2]深圳市宝安区人民医院药剂科,广东深圳518101 [3]深圳市宝安区妇幼保健院儿科,广东深圳518133

出　　处：《中国药房》2015年第9期1211-1213,共3页China Pharmacy

摘　　要：目的：观察阿奇霉素治疗支原体肺炎患儿的临床疗效和安全性。方法 ：将170例支原体肺炎患儿随机均分为对照组和观察组。两组患儿均给予氨溴索、布地奈德、异丙托溴铵等常规治疗。在此基础上,观察组患儿给予阿奇霉素干混悬剂10 mg/kg,口服,每日1次,连用3 d,停药4 d,再用3 d;对照组患儿给予注射用乳糖酸红霉素20~30 mg/kg,加入0.9%氯化钠注射液使乳糖酸红霉素浓度控制在1%~50%,静脉滴注,每日2次。两组患儿疗程均为2周。观察两组患儿的临床疗效、治疗前后心肌酶指标[天冬氨酸氨基转移酶（AST）、乳酸脱氢酶（LDH）、肌酸激酶（CK）、肌酸激酶同工酶（CK-MB）]、白介素（IL）6、IL-18及不良反应发生情况。结果：观察组患儿的总有效率显著高于对照组,不良反应发生率显著低于对照组,差异均有统计学意义（P〈0.05）。治疗前两组患儿AST、LDH、CK、CK-MB、IL-6、IL-18比较,差异均无统计学意义（P〉0.05）;治疗后两组患儿AST、LDH、CK、CK-MB、IL-6、IL-18均显著低于同组治疗前,且观察组显著低于对照组,差异均有统计学意义（P〈0.05）。结论 ：阿奇霉素治疗支原体肺炎患儿疗效显著,且安全性较好。OBJECTIVE：To observe the clinical effect and safety of Azithromycin in treatment of children with mycoplasma pneumonia. METHODS：A total of 170 children with mycoplasma pneumonia were randomly divided into control group and observation group. They were all given conventional treatment,including ambroxol,budesonide,ipratropium bromide,etc. Based on it,observation group was orally given azithromycin dry suspension 10 mg/kg for 3 days,once a day,stopped 4 days and then continually for 3 days. Control group was given erythromycin lactobionate injection 20-30 mg/kg in 0.9% sodium chloride injection to control the concentration of erythromycin lactobionate in the range of 1%-50% with intravenous infusion,twice a day. The course was2 weeks. The clinic data was observed,including clinical efficacy,myocardial enzyme index [aspartate aminotransferase（AST）,lactate dephdrogenase（LDH）,creatine kinase（CK）,creatine kinase isoenzyme（CK-MB）],interleukin（IL）-6,IL-18 and adverse reactions（ADR）. RESULTS：The total effective rate in observation group was significantly higher and incidence of ADR was significantly lower than control group,with significant differences（P〈0.05）. There were no significant differences among AST,LDH,CK,CK-MB,IL-6 and IL-18 before treatment（P〉0.05）. After treatment,the AST,LDH,CK,CK-MB,IL-6 and IL-18 were significantly lower than the same group before treatment and observation group was lower than control group,with significant differences（P〈0.05）. CONCLUSIONS：Azithromycin is effective in treatment of children with mycoplasmal pneumonia with better safety.

关 键 词：儿童 支原体肺炎 阿奇霉素 心肌酶 

分 类 号：R725.6[医药卫生—儿科]