白喉乌头的化学成分研究  

Study on the Chemical Constituents of Aconitum leucostomum

作　　者：汪芳[1] 赵军 赵翡翠[3] 聂继红[3] 

机构地区：[1]新疆医科大学中医学院,乌鲁木齐830011 [2]新疆维吾尔自治区药物研究所/维吾尔药重点实验室,乌鲁木齐830004 [3]新疆医科大学附属中医医院药学部,乌鲁木齐830000

出　　处：《中国药房》2015年第9期1233-1235,共3页China Pharmacy

基　　金：国家自然科学基金(No.81160498)

摘　　要：目的:研究白喉乌头的化学成分。方法:采用硅胶、Sephadex LH-20等色谱技术分离纯化白喉乌头中的化学成分,根据波谱数据和理化性质进行结构鉴定。结果与结论:共鉴定出了5个化合物,分别为Delvestidine(1)、高乌甲素(2)、N-去乙酰高乌甲素(3)、氨茴酰牛扁碱(4)、冉乌碱(5)。其中,化合物1、5为首次从白喉乌头中获得。OBJECTIVE：To study the chemical constituents of Aconitum leucostomum. METHODS：The chemical constituents of A. leucostomum were isolated and purified by silica gel and Sephadex LH-20 chromatography,etc.. The structures were identified according to spectral data and physicochemical properties. RESULTS CONCLUSION：A total of 5 compounds were identified,including delvestidine（1）,lappaconitine（2）,N-deacetylase lappaconitine（3）,anthranoyllycoctonine（4）,ranaconitine（5）.Compound 1 and 5 are isolated from this plant for the first time.

关 键 词：白喉乌头 生物碱 化学成分 

分 类 号：R284.1[医药卫生—中药学]