高纯度芦丁树脂纯化工艺研究  被引量:2

A Facile and Low-Cost Method for the Large-Scale Purification of High-Purity Rutin

在线阅读下载全文

作  者:冯民昌 田原[1] 贾海洋[1] 廖志新[1] 

机构地区:[1]东南大学化学化工学院,江苏南京211189

出  处:《化工时刊》2015年第2期10-12,18,共4页Chemical Industry Times

基  金:2014年"国家大学生创新创业训练计划"项目(1410286088)

摘  要:以粗品芦丁为原料,以聚苯乙烯基非极性大孔树脂DM-130为固定相,以甲醇-水系统为流动相,采用大孔树脂柱色谱法研究了一种高纯度芦丁的纯化工艺。结果表明,当芦丁原料纯度大于85%,原料/树脂=1/10(m/m),70%的甲醇-水系统时,纯化后的芦丁产品经HPLC检测最高纯度可接近98.60%,产量可达千克量级。该工艺操作简便,成本低,产量大,无污染,且树脂可再生循环使用,适于较大规模生产。所得高纯芦丁可用于标准品、医药、化妆品、食品等行业。Macroporous resin column chromatography( MRCC) method for purification of high-purity rutin was successfully established by using crude rutin as raw materials,macroporous resin DM-130 as stationary phases and methanol-water system as flow phases.The purity of the crude rutin above 85% could all as the raw materials,the optimal process conditions were crude rutin / resin( m / m = 1 /10),and eluted by 70% aqueous methanol( v / v) and methanol in turn.The high-performance liquid chromatography( HPLC) showed that the highest purity of the finally products could up to 98.60% and the yield up to kilogram middleweight.The entire process was easy operation,low cost,steadily,and suitable for industrial mass production.The high-purity rutin could be used as the standard substance,in the pharmaceutical industry,cosmetic industry and food industry,etc.

关 键 词:芦丁 纯化 黄酮 大孔树脂 DM-130 

分 类 号:TQ28[化学工程—有机化工]

 

参考文献:

正在载入数据...

 

二级参考文献:

正在载入数据...

 

耦合文献:

正在载入数据...

 

引证文献:

正在载入数据...

 

二级引证文献:

正在载入数据...

 

同被引文献:

正在载入数据...

 

相关期刊文献:

正在载入数据...

相关的主题
相关的作者对象
相关的机构对象