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出 处:《化工时刊》2015年第2期10-12,18,共4页Chemical Industry Times
基 金:2014年"国家大学生创新创业训练计划"项目(1410286088)
摘 要:以粗品芦丁为原料,以聚苯乙烯基非极性大孔树脂DM-130为固定相,以甲醇-水系统为流动相,采用大孔树脂柱色谱法研究了一种高纯度芦丁的纯化工艺。结果表明,当芦丁原料纯度大于85%,原料/树脂=1/10(m/m),70%的甲醇-水系统时,纯化后的芦丁产品经HPLC检测最高纯度可接近98.60%,产量可达千克量级。该工艺操作简便,成本低,产量大,无污染,且树脂可再生循环使用,适于较大规模生产。所得高纯芦丁可用于标准品、医药、化妆品、食品等行业。Macroporous resin column chromatography( MRCC) method for purification of high-purity rutin was successfully established by using crude rutin as raw materials,macroporous resin DM-130 as stationary phases and methanol-water system as flow phases.The purity of the crude rutin above 85% could all as the raw materials,the optimal process conditions were crude rutin / resin( m / m = 1 /10),and eluted by 70% aqueous methanol( v / v) and methanol in turn.The high-performance liquid chromatography( HPLC) showed that the highest purity of the finally products could up to 98.60% and the yield up to kilogram middleweight.The entire process was easy operation,low cost,steadily,and suitable for industrial mass production.The high-purity rutin could be used as the standard substance,in the pharmaceutical industry,cosmetic industry and food industry,etc.
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