2型糖尿病动脉粥样硬化患者CD4^+CD28^(null)T细胞亚群的表达及意义  

Significance and Expression of CD4+CD28nullT Cell Subset on Progression of Atherosclerosis in Patients with Type 2 Diabetes

作　　者：汤珂珂[1] 高祖华[1] 邱夏桑[1] 颜勤明[1] 

机构地区：[1]浙江省台州医院内分泌科,317000

出　　处：《心脑血管病防治》2015年第1期18-20,共3页CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT

基　　金：浙江省医药卫生科技计划项目(编号:2011KYA160);浙江省台州市科技计划项目(编号:11KY03)

摘　　要：目的探讨CD4+CD28nullT细胞亚群在2型糖尿病动脉粥样硬化发生发展中的作用。方法根据彩色多普勒超声检查结果,将92例2型糖尿病患者分为颈动脉粥样硬化组与对照组,采用流式细胞仪检测分析颈动脉粥样硬化组和对照组外周血CD4+CD28nullT细胞亚群的表达情况,并分析其与年龄、C反应蛋白(CRP)、血糖、血脂、体质指数(BMI)、腰围、臀围、舒张压、收缩压的关系。结果颈动脉粥样硬化组CD4+CD28nullT细胞亚群的表达明显高于对照组,分别为(4.40±2.95)%和(3.04±2.20)%,差异有统计学意义(P<0.05)。CD4+CD28nullT细胞亚群的表达与年龄、CRP、糖化血红蛋白(Hb A1c)相关(r=0.20~0.25,P<0.05)。控制年龄和Hb A1c因素后,CD4+CD28nullT细胞亚群的表达与CRP仍相关(r=0.24,P<0.05)。结论 2型糖尿病动脉粥样硬化患者具有更高的CD4+CD28null T细胞表达。CD4+CD28nullT细胞亚群可能通过介导炎症反应影响2型糖尿病患者动脉粥样硬化的发生和发展。Objective To investigate the effect of CD4^＋CD28^nullT cell subset on occurrence and progress of atherosclerosis in patients with type 2 diabetes. Methods 92 patients with type 2 diabetes were divided into the carotid atherosclerosis group and control group according to the detecting results by color doppler ultrasound. The expressions of CD4^＋CD28^nullT cell subset in peripheral blood of the carotid atherosclerosis and control groups were detected by a flow cytometry. The relationships between the expression of CD4^＋CD28^nullT cell subset and age,C react protein（ CRP）,blood glucose,blood lipid,body mass index（ BMI）,waist circumference,hip circumference,diastolic blood pressure,systolic blood pressure were also analyzed. Results The expression of CD4^＋CD28^nullT cell subset of the carotid atherosclerosis group is significantly higher than that of the control group（ 4. 40 ± 2. 95% vs. 3. 04 ± 2. 20%,P〈0. 05）. The expressions of CD4^＋CD28^nullT cell subset were correlated with age,CRP,Hemoglobin A1C（ Hb A1c）（ r- 0. 20 - 0. 25,P〈0. 05）. After controlling the factors of age and Hb A1 c,the expression of CD4^＋CD28^nullT cell subset was still relevant with CRP（ r = 0. 24,P〈0. 05）. Conclusions The type 2 diabetes patients with atherosclerosis have a higher expression of CD4^＋CD28^nullT lymphocyte. CD4^＋CD28^nullT cell subset may affect the occurrence and process of atherosclerosis via mediated inflammatory response in the patients with type 2 diabetes.

关 键 词：糖尿病 T细胞亚群 多普勒超声 

分 类 号：R587.1[医药卫生—内分泌]