托伐普坦治疗心力衰竭的症状改善作用及对心肾功能的影响  

Improvement of Tolvaptan for Treating Heart Failure Symptoms and Its Influence on Cardial and Renal Function

作　　者：李永超[1] 赵月[1] 赵瑞革[1] 英海荣 

机构地区：[1]辽宁省阜新市中心医院,辽宁阜新123000

出　　处：《中国药业》2015年第6期19-20,共2页China Pharmaceuticals

摘　　要：目的探讨托伐普坦对心力衰竭患者症状的改善作用及对心肾功能的影响。方法选择2013年收治的慢性心力衰竭患者106例,按随机数字表法将其分为观察组和对照组,各53例。两组患者均给予强心剂、利尿剂及纠正水电解质紊乱等常规治疗,观察组加用托伐普坦15 mg/d。观察两组患者呼吸困难、肺部罗音及下肢水肿等症状的改善情况,比较治疗后患者心、肾功能指标的变化。结果治疗后,与对照组患者相比,观察组患者呼吸困难、肺部罗音、下肢水肿等心力衰竭症状及心功能各项指标均显著得到改善,24 h尿量显著增多,脑利钠肽(BNP)水平显著降低(P<0.05),肾功能无明显影响。结论托伐普坦有助于改善心力衰竭患者的不适等症状和心功能,不会引起肾脏功能衰竭,值得临床推广。Objective To explore the effect of tolvaptan on improving the symptoms in the patients with heart failure and its influence on the cardial and renal function. Methods 146 patients with chronic heart failure admitted our hospital in 2013 were selected and divided into the observation group and the control group according to the random number table method,53 cases in each group. Both the two groups were treated with the conventional therapy of carditonic,diuretic,correcting water and electrolyte disturbance,etc. The observation group was added with tolvaptan 15 mg / d. The symptoms improvement situation such as dyspnea,pulmonary rales and lower extremity edema were observed in the two groups. The changes of the cardial and renal function indexes after treatment were compared between the two groups. Results Compared with the control group,the heart failure symptoms of dyspnea,pulmonary rales and lower extremity edema after treatment in the observation group were significantly improved,24 h urine output was significantly increased and BNP was significantly dropped（ P 0. 05）,the renal function had no obvious deterioration. Conclusion Tolvaptan conduces to improve the discomfort symptoms in the heart failure patients without causing the kidney function failure,which is worthy of clinical promotion.

关 键 词：托伐普坦 心力衰竭 心功能 肾功能 

分 类 号：R969.4[医药卫生—药理学] R972.1[医药卫生—药学]