血清Fibulin-3水平与脉搏波传导速度在高血压血管重构中的作用  

The correlation between Fibulin-3 and Pulse Wave Velocity in patients with hypertension

作　　者：林忠伟[1,2] 王卓[3] 李瑞莹[4] 向定成[5] 

机构地区：[1]南方医科大学研究生院 [2]广东药学院附属第一医院心内科,广州市510080 [3]中山大学附属第一医院病理科,广州市510080 [4]广东药学院附属第一医院检验科,广州市510080 [5]广州军区广州总医院心内科,510110

出　　处：《实用医学杂志》2015年第5期743-746,共4页The Journal of Practical Medicine

基　　金：广东省科技厅科研立项(编号:2013B021800086);广东药学院附属第一医院科研立项(编号:201302)

摘　　要：目的:探讨高血压患者血清Fibulin-3水平改变的临床意义及其与肱-踝脉搏波传导速度(branchial-ankle pulse wave velocity,ba PWV)的相关性在高血压血管重构中的作用。方法 :收集我院住院及门诊就诊高血压患者50例以及体检的健康人38例作为对照人群,空腹抽血后分离血清,以酶联免疫吸附(ELISA)方法检测血清Fibulin-3、MMP-9表达;采用脉搏波速度自动测定仪测定baPWV。结果:高血压患者血清Fibulin-3水平较正常人明显下降,差异有统计学意义(P<0.001);而血清MMP-9水平在两组间差异无统计学意义(P>0.05);高血压患者baPWV较正常人明显升高,差异有统计学意义(P<0.001)。高血压患者血清Fibulin-3水平与baPWV之间进行相关性分析,两者呈负相关(r=-0.324,P=0.006);而MMP-9和baPWV之间进行相关性分析,显示无相关性(r=0.003,P=0.968)。结论:高血压血管重构存在细胞外基质的变化和动脉功能改变,检测血清Fibulin-3水平和baPWV可作为高血压早期反映动脉功能改变的指标之一,对判断高血压靶器官损害有一定帮助。Objective To investigate the changes and significances of the level of serum Fibulin-3 and correlation between Fibulin-3 and branchial-ankle Pulse Wave Velocity （baPWV） in patients with hypertension. Methods A total of 50 patients with hypertension and 38 healthy people were enrolled finally, whose fasting blood were collected. The levels of Fibulin-3、MMP-9 were detected by enzyme-linked immunosorbent assay. The baPWV was detected by pulse wave velocity automatic analyzer. Results The level of serum Fibulin-3 in hypertension was lower than the control group significantly （P 〈 0.001）. There was no significance of serum MMP-9 in the two groups. The baPWV in hypertension was higher than the control group.Correlations between the level of Fibulin-3 and baPWV were significant （r = -0.324,P = 0.006）. While correlations between the level of MMP-9 and baPWV had no significance （r=0.003,P=0.968）. Conclusion The level of serum Fibulin-3 and baPWV can be used as index of functional changes in the early stage of hypertensive vascular remodeling, and may be applied for forecasting the organ damage in hypertension.

关 键 词：高血压 血管重构 Fibulin-3 脉搏波传导速度 

分 类 号：R544.1[医药卫生—心血管疾病]