星形聚合物作为纳米药物载体的研究进展  

Star-shaped block polymers for nanomedicine development

作　　者：高永峰[1] 曾小伟[1] 冯思慎 梅林[1] 

机构地区：[1] 清华大学深圳研究生院,深圳518055 [2] 新加坡国立大学化学与生物分子工程系,117576

出　　处：《国际生物医学工程杂志》2015年第1期52-56,I0008,共6页International Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目（31270019,51203085）;教育部新世纪优秀人才资助项目（NCET-11-0275）

摘　　要：在纳米医药领域,星形高分子聚合物因其生物学性能独特、适用性广而引起了广泛关注.与线形和高支化聚合物相比,星形聚合物的独特结构特性在作为纳米递送载体方面更具优势.星形聚合物已成为一种潜在的有望用于疾病治疗和诊断的纳米靶向生物材料.为此,综述了星形聚合物及其作为药物和基因纳米载体的相关研究进展.Star-shaped block polymers have recently attracted considerable attention owing to their unique properties and applicability in nanomedicine development.Compare to linear polymer and hyper-branched polymers,star-shaped block polymers have more advantages due to the unique structure.Star-shaped block polymer has become a desirable molecular biomaterial for delivery therapeutics and diagnostic agent to the diseased cells.This paper reviews the research about star-shaped block polymers and nanomedicine development in using them as drug and gene delivery carriers.

关 键 词：星形聚合物 纳米医学 纳米载体 靶向递送 

分 类 号：R318[医药卫生—生物医学工程] TB383[医药卫生—基础医学]